Natta C, Creque L, Navarro C
Am J Clin Pathol. 1985 Jan;83(1):76-8. doi: 10.1093/ajcp/83.1.76.
In autopsy studies of two sickle cell anemia (SCA) patients, iron was totally absent from all organs in one case in which the serum ferritin had been low, while the other patient demonstrated hepatic, splenic, and renal siderosis but no iron stores in the bone marrow. Serum ferritin had been very high in this case. These findings suggest that in SCA bone marrow biopsy may be an unreliable means to determine iron stores, but rather the ferritin level should be used.
在对两名镰状细胞贫血（SCA）患者进行的尸检研究中，一例血清铁蛋白水平较低的患者，其所有器官均完全没有铁，而另一例患者则表现出肝脏、脾脏和肾脏的铁沉着症，但骨髓中没有铁储存。该病例的血清铁蛋白水平一直非常高。这些发现表明，在镰状细胞贫血中，骨髓活检可能是确定铁储存的不可靠方法，而应使用铁蛋白水平。
