• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

中西医结合治疗干燥综合征的网状Meta分析

Network meta-analysis of integrated traditional Chinese and Western medicine in the treatment of Sjogren's syndrome.

作者信息

Ma Xieli, Liu Zixia, Chang Tian, Yao Chuanhui, Yang Yuchen, Shang Biyue, Liu Jiameng, Xia Congmin, Gong Xun, Jiang Quan

机构信息

Department of Rheumatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

出版信息

Front Pharmacol. 2024 Nov 27;15:1455969. doi: 10.3389/fphar.2024.1455969. eCollection 2024.

DOI:10.3389/fphar.2024.1455969
PMID:39664524
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11631580/
Abstract

OBJECTIVE

To evaluate efficacy and safety of traditional Chinese medicine (TCM) combined with Western medicine in treatment of Sjogren's syndrome (SS).

METHODS

CNKI, WanFang, VIP, CBM, Sinomed, PubMed, Embase, and Web of Science were searched to collect randomized controlled trials (RCTs) of TCM combined with conventional western medicine (CWM) in treating SS from the time of their estalishment to May 2023. The researchers independently screened the literature and extracted data for quality evaluation. Analyses were performed using Review Manager (version 5.4) and R-4.3.1.

RESULTS

A total of 66 RCTs were included, with a sample size of 5,052, involving four kinds of TCM (total glucosides of paeony capsules, tripterygium glycosides tablet, Xinfeng capsule and Jinju Qingrun capsule) and three kinds of CWM(hydroxychloroquine sulfate, Iguratimod and glucocorticoid). The network meta-analysis results showed that IGU + HCQ + TGP ranked the highest in reducing ESR and IgG and improving the Schirmer test when the three drugs were combined. When the two drugs are combined, IGU + GC and TGT + TGP are good choices for reducing erythrocyte sedimentation rate (ESR) and Immunoglobulin G (IgG). Although TGP + HCQ vs. HCQ had the most studies, TGP combined with HCQ did not rank high in each outcome indicator. It is recommended to use TGT and XFG in decreasing ESR and IgG for a single drug. JJQR have an advantageous role in relieving xerostomia and dry eyes.

CONCLUSION

TCM combined with CWM has a very significant effect on treating SS compared with CWM alone. According to the network meta-analysis, the best intervention measures of different TCMs for different outcome indicators were obtained.

SYSTEMATIC REVIEW REGISTRATION

[https://www.crd.york.ac.uk/prospero/], identifier [CRD42023451845].

摘要

目的

评价中西医结合治疗干燥综合征（SS）的疗效和安全性。

方法

检索中国知网、万方、维普、中国生物医学文献数据库、中国中医药期刊文献数据库、PubMed、Embase和Web of Science，收集自建库至2023年5月中西医结合治疗SS的随机对照试验（RCT）。研究人员独立筛选文献并提取数据进行质量评估。使用RevMan（5.4版）和R-4.3.1进行分析。

结果

共纳入66项RCT，样本量为5052，涉及4种中药（白芍总苷胶囊、雷公藤多苷片、新风胶囊和金菊清润胶囊）和3种西药（硫酸羟氯喹、艾拉莫德和糖皮质激素）。网状Meta分析结果显示，三种药物联合使用时，艾拉莫德+羟氯喹+白芍总苷在降低血沉和免疫球蛋白G（IgG）以及改善泪液分泌试验方面排名最高。两种药物联合使用时，艾拉莫德+糖皮质激素和雷公藤多苷+白芍总苷是降低血沉（ESR）和免疫球蛋白G（IgG）的良好选择。虽然白芍总苷+羟氯喹与羟氯喹的研究最多，但白芍总苷联合羟氯喹在各结局指标中排名不高。单药治疗时，推荐使用雷公藤多苷和新风胶囊降低血沉和IgG。金菊清润胶囊在缓解口干和眼干方面具有优势作用。

结论

与单纯西药相比，中西医结合治疗SS有非常显著的效果。根据网状Meta分析，获得了不同中药针对不同结局指标的最佳干预措施。

系统评价注册

[https://www.crd.york.ac.uk/prospero/]，标识符[CRD42023451845]

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/645807d73d5f/fphar-15-1455969-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/8d0eee28bd9c/fphar-15-1455969-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/18aa7fbae188/fphar-15-1455969-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/1a8b0451384f/fphar-15-1455969-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/c206958adb8b/fphar-15-1455969-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/4fda803f249d/fphar-15-1455969-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/056863a45ca9/fphar-15-1455969-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/a14e0f048403/fphar-15-1455969-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/645807d73d5f/fphar-15-1455969-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/8d0eee28bd9c/fphar-15-1455969-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/18aa7fbae188/fphar-15-1455969-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/1a8b0451384f/fphar-15-1455969-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/c206958adb8b/fphar-15-1455969-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/4fda803f249d/fphar-15-1455969-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/056863a45ca9/fphar-15-1455969-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/a14e0f048403/fphar-15-1455969-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3bde/11631580/645807d73d5f/fphar-15-1455969-g008.jpg

相似文献

1
Network meta-analysis of integrated traditional Chinese and Western medicine in the treatment of Sjogren's syndrome.中西医结合治疗干燥综合征的网状Meta分析
Front Pharmacol. 2024 Nov 27;15:1455969. doi: 10.3389/fphar.2024.1455969. eCollection 2024.
2
Combined use of total glucosides of paeony and hydroxychloroquine in primary Sjögren's syndrome: A systematic review.白芍总苷联合羟氯喹治疗原发性干燥综合征的系统评价。
Immun Inflamm Dis. 2023 Oct;11(10):e1044. doi: 10.1002/iid3.1044.
3
Effectiveness and Safety of Iguratimod in Treating Primary Sjögren's Syndrome: A Systematic Review and Meta-Analysis.艾拉莫德治疗原发性干燥综合征的有效性和安全性：一项系统评价与Meta分析
Front Pharmacol. 2021 Mar 19;12:621208. doi: 10.3389/fphar.2021.621208. eCollection 2021.
4
Efficacy and safety of Tripterygium glycosides in Sjögren's syndrome treatment: evidence from 12 randomized controlled trials.雷公藤多苷治疗干燥综合征的疗效和安全性：来自 12 项随机对照试验的证据。
Ann Palliat Med. 2021 Jul;10(7):8215-8231. doi: 10.21037/apm-21-256. Epub 2021 Jul 5.
5
Efficacy and safety of oral Chinese patent medicine for benign prostatic hyperplasia: a network meta-analysis of randomized controlled trials.口服中成药治疗良性前列腺增生的疗效与安全性：一项随机对照试验的网状Meta分析
Front Med (Lausanne). 2024 Dec 27;11:1483864. doi: 10.3389/fmed.2024.1483864. eCollection 2024.
6
The Effectiveness and Safety of Total Glucosides of Paeony in Primary Sjögren's Syndrome: A Systematic Review and Meta-Analysis.白芍总苷在原发性干燥综合征中的有效性和安全性：一项系统评价与Meta分析
Front Pharmacol. 2019 May 24;10:550. doi: 10.3389/fphar.2019.00550. eCollection 2019.
7
Efficacy of Chinese traditional patent medicines for heart failure with preserved ejection fraction: a Bayesian network meta-analysis of 64 randomized controlled trials.中成药治疗射血分数保留的心力衰竭的疗效：64项随机对照试验的贝叶斯网络荟萃分析
Front Cardiovasc Med. 2023 Nov 20;10:1255940. doi: 10.3389/fcvm.2023.1255940. eCollection 2023.
8
[Network Meta-analysis of efficacy of Chinese patent medicine in treatment of inflammatory response in diabetic nephropathy].[中成药治疗糖尿病肾病炎症反应疗效的网状Meta分析]
Zhongguo Zhong Yao Za Zhi. 2023 Jul;48(13):3633-3649. doi: 10.19540/j.cnki.cjcmm.20230330.501.
9
Efficacy and safety of traditional Chinese medicines combined with conventional Western medicines in the treatment of type 2 diabetes mellitus: a network meta-analysis of randomized controlled trials.中药联合常规西药治疗 2 型糖尿病的疗效和安全性：一项随机对照试验的网络荟萃分析。
Front Endocrinol (Lausanne). 2023 May 8;14:1134297. doi: 10.3389/fendo.2023.1134297. eCollection 2023.
10
Clinical safety of total glucosides of paeony adjuvant therapy for rheumatoid arthritis treatment: a systematic review and meta-analysis.白芍总苷辅助治疗类风湿关节炎的临床安全性：系统评价和荟萃分析。
BMC Complement Med Ther. 2021 Mar 26;21(1):102. doi: 10.1186/s12906-021-03252-y.

引用本文的文献

1
Exploring the immunomodulatory mechanism of total glucosides of paeony on Sjögren's syndrome dry eye disease based on the "gut-eye axis" pathway.基于“肠-眼轴”通路探讨白芍总苷对干燥综合征干眼疾病的免疫调节机制。
Int Ophthalmol. 2025 Jun 5;45(1):230. doi: 10.1007/s10792-025-03607-1.

本文引用的文献

1
Update on the pathophysiology and treatment of primary Sjögren syndrome.原发性干燥综合征的病理生理学和治疗进展。
Nat Rev Rheumatol. 2024 Aug;20(8):473-491. doi: 10.1038/s41584-024-01135-3. Epub 2024 Jul 9.
2
Network pharmacology and molecular docking analysis on the mechanism of Tripterygium wilfordii Hook in the treatment of Sjögren syndrome.基于网络药理学和分子对接的方法研究雷公藤治疗干燥综合征的作用机制。
Medicine (Baltimore). 2024 Apr 5;103(14):e37532. doi: 10.1097/MD.0000000000037532.
3
Epidemiology of Sjögren syndrome.干燥综合征的流行病学。
Nat Rev Rheumatol. 2024 Mar;20(3):158-169. doi: 10.1038/s41584-023-01057-6. Epub 2023 Dec 18.
4
A single-cell landscape of triptolide-associated testicular toxicity in mice.雷公藤甲素诱导小鼠睾丸毒性的单细胞图谱
J Pharm Anal. 2023 Aug;13(8):880-893. doi: 10.1016/j.jpha.2023.04.006. Epub 2023 Apr 14.
5
Current and future therapies for primary Sjögren syndrome.原发性干燥综合征的当前和未来治疗方法。
Nat Rev Rheumatol. 2021 Aug;17(8):475-486. doi: 10.1038/s41584-021-00634-x. Epub 2021 Jun 29.
6
Total glucosides of paeony (TGP) alleviates Sjogren's syndrome through inhibiting inflammatory responses in mice.白芍总苷（TGP）通过抑制小鼠的炎症反应缓解干燥综合征。
Phytomedicine. 2020 Jun;71:153203. doi: 10.1016/j.phymed.2020.153203. Epub 2020 Mar 6.
7
[Efficay Observation of Xinfeng Capsule for Treating 58 Cases of Sjogren's Syndrome].[新风胶囊治疗干燥综合征58例疗效观察]
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2016 Nov;36(11):1323-1328.
8
Primary Sjögren's Syndrome.原发性干燥综合征
N Engl J Med. 2018 Mar 8;378(10):931-939. doi: 10.1056/NEJMcp1702514.
9
2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome: A consensus and data-driven methodology involving three international patient cohorts.2016 年美国风湿病学会/欧洲抗风湿病联盟原发性干燥综合征分类标准：一项涉及三个国际患者队列的共识和数据驱动方法。
Ann Rheum Dis. 2017 Jan;76(1):9-16. doi: 10.1136/annrheumdis-2016-210571. Epub 2016 Oct 26.
10
Sjögren syndrome.干燥综合征。
Nat Rev Dis Primers. 2016 Jul 7;2:16047. doi: 10.1038/nrdp.2016.47.