Moriya Ayano, Nakato Eriko, Li Jin-Ping, Nakato Hiroshi
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota, USA.
Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Proteoglycan Res. 2024 Oct-Dec;2(4). doi: 10.1002/pgr2.70009. Epub 2024 Nov 5.
Chondroitin sulfate (CS) is one of the most evolutionarily conserved glycosaminoglycans (GAGs). Although CS's function in skeletal development is well established in vertebrates, CS exists in more primitive animal species with no cartilage or bone, such as and , indicating that the original role of CS was not in the skeletal system. In this review, we focus on the roles of CS and the mechanisms of action during development of two genetically trackable model organisms, and .
硫酸软骨素（CS）是进化上最保守的糖胺聚糖（GAGs）之一。尽管CS在脊椎动物骨骼发育中的功能已得到充分证实，但CS也存在于没有软骨或骨骼的更原始动物物种中，如 和 ，这表明CS的原始作用并非在骨骼系统中。在本综述中，我们重点关注CS在两种具有遗传可追踪性的模式生物 和 发育过程中的作用及作用机制。
