Tang Yunyu, Liu Ruen
Department of Neurosurgery, Peking University People's Hospital, Beijing, China.
Can J Neurol Sci. 2024 Dec 12:1-9. doi: 10.1017/cjn.2024.326.
To compare structural alterations in the brains of Meige syndrome (MS) patients with those of healthy controls (HCs) by using surface-based morphometry (SBM) and compare structural differences between the brains of MS patients with sleep disorders and those of MS patients without sleep disorders.
We investigated cortical surface parameters in 42 MS patients and 30 HCs. T1-weighted images were acquired and processed using CAT12 to perform vertexwise between-group comparisons of cortical thickness, gyrification, cortical complexity and sulcus depth with validated quality control protocols. We also performed SBM to analyze data from 19 patients with sleep disorders and 23 patients without sleep disorders.
Compared with HCs, MS patients had differences in large clusters of cortical regions, especially in postcentral, precentral, superior frontal and paracentral thickness. Differences were also observed in the parietal and occipital areas. Among MS patients with and without sleep disorders, altered cortical complexity and sulcal depth were observed.
This study strongly suggested that MS patients have cortical structural abnormalities compared with HCs, thus elucidating the underlying pathophysiology of motor and nonmotor symptoms in MS patients.
通过基于表面的形态测量法（SBM）比较梅杰综合征（MS）患者与健康对照者（HCs）大脑的结构改变，并比较伴有睡眠障碍的MS患者与不伴有睡眠障碍的MS患者大脑的结构差异。
我们研究了42例MS患者和30例HCs的皮质表面参数。采集T1加权图像并使用CAT12进行处理，以采用经过验证的质量控制方案对皮质厚度、脑回化、皮质复杂性和脑沟深度进行顶点间组间比较。我们还进行了SBM以分析19例伴有睡眠障碍的患者和23例不伴有睡眠障碍的患者的数据。
与HCs相比，MS患者在大量皮质区域存在差异，尤其是中央后回、中央前回、额上回和中央旁小叶厚度。在顶叶和枕叶区域也观察到差异。在伴有和不伴有睡眠障碍的MS患者中，观察到皮质复杂性和脑沟深度改变。
本研究强烈提示，与HCs相比，MS患者存在皮质结构异常，从而阐明了MS患者运动和非运动症状的潜在病理生理学。
