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FKBP12缺失在扩张型心肌病发展过程中的时间依赖性效应。

Time-dependent effect of FKBP12 loss in the development of dilated cardiomyopathy.

作者信息

Chan Joan A, Munro Michelle L

机构信息

Department of Physiology, School of Biomedical Sciences and HeartOtago, University of Otago, Dunedin, New Zealand.

Brain Health Research Centre, University of Otago , Dunedin, New Zealand.

出版信息

J Gen Physiol. 2025 Jan 6;157(1). doi: 10.1085/jgp.202413673. Epub 2024 Dec 12.

DOI:10.1085/jgp.202413673
PMID:39665747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11636550/
Abstract

Hanna et al. reveal that early, but not late, developmental cardiac FKBP12 deficiency leads to dilated cardiomyopathy in the adult heart.

摘要

汉娜等人发现，发育早期而非晚期的心脏FKBP12缺乏会导致成年心脏出现扩张型心肌病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69be/11636550/f378fa621d5c/jgp_202413673_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69be/11636550/f378fa621d5c/jgp_202413673_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69be/11636550/f378fa621d5c/jgp_202413673_fig1.jpg

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本文引用的文献

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J Gen Physiol. 2025 Jan 6;157(1). doi: 10.1085/jgp.202413583. Epub 2024 Dec 11.
2
Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.肌质网钙释放通道蛋白 2 在心衰和心律失常性疾病中发生渗漏的结构基础。
Nat Commun. 2024 Sep 15;15(1):8080. doi: 10.1038/s41467-024-51791-y.
3
Clustering properties of the cardiac ryanodine receptor in health and heart failure.健康和心力衰竭中心脏兰尼碱受体的聚类特性。
J Mol Cell Cardiol. 2023 Dec;185:38-49. doi: 10.1016/j.yjmcc.2023.10.012. Epub 2023 Oct 27.
4
FKBP12 binds to the cardiac ryanodine receptor with negative cooperativity: implications for heart muscle physiology in health and disease.FKBP12 与心脏兰尼碱受体以负协同方式结合：对健康和疾病中心肌生理学的影响。
Philos Trans R Soc Lond B Biol Sci. 2023 Jun 19;378(1879):20220169. doi: 10.1098/rstb.2022.0169. Epub 2023 May 1.
5
Mutation in RyR2-FKBP Binding site alters Ca signaling modestly but increases "arrhythmogenesis" in human stem cells derived cardiomyocytes.RYR2-FKBP 结合位点突变可适度改变钙信号，但增加源自人类干细胞的心肌细胞中的“心律失常发生”。
Cell Calcium. 2022 Jan;101:102500. doi: 10.1016/j.ceca.2021.102500. Epub 2021 Nov 8.
6
Cardiac ryanodine receptor distribution is dynamic and changed by auxiliary proteins and post-translational modification.心肌兰尼碱受体的分布是动态的，并受辅助蛋白和翻译后修饰的影响。
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