Agudelo Jose, Mukherjee Sromona, Suryavanshi Mangesh, Ljubetic Bernardita, Lindenbaum Marcelo Mass, Miller Aaron W
Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland, OH, USA.
Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.
Eur Urol Focus. 2024 Dec;10(6):902-905. doi: 10.1016/j.euf.2024.11.010. Epub 2024 Dec 10.
Nephrolithiasis imposes a significant health care burden around the world. In the past decade, there has been considerable interest in the human microbiota in relation to the onset of nephrolithiasis. Most of the research has focused on degradation of oxalate, a known causative factor for nephrolithiasis, by bacteria in the gut. More recently, the role of antibiotic exposure and changes to short-chain fatty acids have been investigated. Studies have revealed that the urinary tract, previously thought to be sterile, harbors resident microbial communities closely associated with nephrolithiasis. In this mini-review, we evaluate potential causative roles of the microbiome in the onset of nephrolithiasis and the development of novel therapies to prevent this disease. PATIENT SUMMARY: This mini-review discusses scientific evidence on the influence of bacteria in our intestines and urinary tract on the formation of kidney stones. We discuss possible therapies targeting these bacteria that could prevent kidney stones from forming.
肾结石在全球范围内给医疗保健带来了沉重负担。在过去十年中，人们对人类微生物群与肾结石发病之间的关系产生了浓厚兴趣。大多数研究集中在肠道细菌对草酸盐的降解作用，草酸盐是肾结石的一个已知致病因素。最近，抗生素暴露和短链脂肪酸变化的作用也得到了研究。研究表明，以前被认为无菌的泌尿道中存在与肾结石密切相关的常驻微生物群落。在这篇小型综述中，我们评估了微生物群在肾结石发病中的潜在致病作用以及预防该疾病的新疗法的开发。患者总结：这篇小型综述讨论了关于我们肠道和泌尿道中的细菌对肾结石形成影响的科学证据。我们讨论了针对这些细菌的可能疗法，这些疗法可以预防肾结石的形成。
