哌仑西平与西咪替丁治疗十二指肠溃疡的比较。
Pirenzepine versus cimetidine in the treatment of duodenal ulcer.
作者信息
Bianchi Porro G, Petrillo M, Lazzaroni M, Dal Monte P R, D'Imperio N, Giuliani Piccari G
出版信息
Scand J Gastroenterol Suppl. 1979;57:59-62.
Fifty-five patients with active duodenal ulcer have completed, up to today, a one-month double-blind trial to compare the effects of pirenzepine (150 mg daily), cimetidine (1 g daily) and placebo on the healing of duodenal ulcer. Fifteen (71%) of the 21 patients treated with pirenzepine had healed ulcers compared with 14 (82%) receiving cimetidine (P less than 0.05. In the placebo group there were 7 (41%) healed ulcers. Symptomatic improvement in patients given pirenzepine was as substantial as in cimetidine-treated patients. No adverse effects were noted.
截至今日，55名活动性十二指肠溃疡患者完成了一项为期一个月的双盲试验，以比较哌仑西平（每日150毫克）、西咪替丁（每日1克）和安慰剂对十二指肠溃疡愈合的影响。接受哌仑西平治疗的21名患者中有15名（71%）溃疡愈合，而接受西咪替丁治疗的患者中有14名（82%）溃疡愈合（P小于0.05）。在安慰剂组中，有7名（41%）溃疡愈合。接受哌仑西平治疗的患者症状改善程度与接受西咪替丁治疗的患者相当。未观察到不良反应。
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