肺移植术后阻塞性睡眠呼吸暂停与血清标志物低氧诱导因子-1、白细胞介素-6和诱导型一氧化氮合酶之间的相关性

Correlation between obstructive sleep apnea and serum markers HIF-1, IL-6 and iNOS after lung transplantation.

作者信息

Li Qi, Yu Huaqing, Wang Chao, Gu Jingxiao, Yang Hang, Wan Rongrong, Zhang Yunyun, Hu Chunxiao, Cui Xiaochuan

机构信息

General Practice, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214000, China.

Lung transplant center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, 214000, China.

出版信息

Sleep Breath. 2024 Dec 12;29(1):58. doi: 10.1007/s11325-024-03229-4.

DOI:10.1007/s11325-024-03229-4

PMID:39666244

Abstract

PURPOSE

To analyze the correlation between obstructive sleep apnea (OSA) and hypoxia-inducible factor (HIF)-1, interleukin (IL)-6 and inducible nitric oxide synthase (iNOS) in patients complicated with OSA after lung transplantation. To identify serum markers of OSA after lung transplantation.

METHODS

We retrospectively selected patients who planned to undergo lung transplantation between 2018 and 2020, including 25 without OSA before lung transplantation (group A), 20 with OSA after lung transplantation (group B), and 15 patients without OSA after lung transplantation (group C). Sleep monitoring was performed, general information collection and hematological samples were collected. HIF-1, IL-6 and iNOS were detected by ELISA.

RESULTS

Group B were older [59.2 ± 10.1 (B) vs. 49.8 ± 15.1 (A), 58.2 ± 3.3 (C), yrs.], had a bigger neck circumference [38.1 ± 4.7 (B) vs. 34.6 ± 4.2 (A),35.7 ± 4.2 (C), cm], and a greater abdominal circumference [88.2 ± 12.5 (B) vs. 76.2 ± 7.9 (A), 82.5 ± 6.5 (C), cm] compared with Groups A and C (P < 0.05). iNOS in group B (4784.8 ± 1365.2 (B) vs. 1925.2 ± 1868.5 (A), 2838.7 ± 3015.5 (C), pg/mL) was significantly increased compared to groups A and C (P < 0.05). iNOS was positively correlated with AHI.

CONCLUSIONS

iNOS is significantly increased in OSA after lung transplantation, and maybe an important indicator of OSA.

摘要

目的

分析肺移植术后合并阻塞性睡眠呼吸暂停（OSA）患者的OSA与缺氧诱导因子（HIF）-1、白细胞介素（IL）-6和诱导型一氧化氮合酶（iNOS）之间的相关性。确定肺移植术后OSA的血清标志物。

方法

回顾性选取2018年至2020年间计划接受肺移植的患者，包括25例肺移植术前无OSA者（A组）、20例肺移植术后发生OSA者（B组）和15例肺移植术后无OSA者（C组）。进行睡眠监测，收集一般资料并采集血液样本。采用酶联免疫吸附测定法检测HIF-1、IL-6和iNOS。

结果

与A组和C组相比，B组年龄更大[59.2±10.1（B）岁 vs. 49.8±15.1（A）岁，58.2±3.3（C）岁]，颈围更大[38.1±4.7（B）cm vs. 34.6±4.2（A）cm，35.7±4.2（C）cm]，腹围更大[88.2±12.5（B）cm vs. 76.2±7.9（A）cm，82.5±6.5（C）cm]（P<0.05）。与A组和C组相比，B组的iNOS显著升高[4784.8±1365.2（B）pg/mL vs. 1925.2±1868.5（A）pg/mL，2838.7±3015.5（C）pg/mL]（P<0.05）。iNOS与呼吸暂停低通气指数（AHI）呈正相关。