Phase II trial of Prednimustine. Leo-1031 (NSC-134087) in acute non-lymphocytic leukemia.
作者信息
Juul K, Sørensen P, Pedersen-Bjergaard J, Jensen M K
出版信息
Scand J Haematol. 1979 Nov;23(5):388-92. doi: 10.1111/j.1600-0609.1979.tb02738.x.
Abstract
18 patients with acute non-lymphocytic leukaemia were treated with Prednimustine, a chlorambucil ester of prednisolone, as a single drug. 5 patients responded with falling blast counts in peripheral blood, but only 1 obtained a complete remission of 3 months' duration. Since the activity of Prednimustine is lower than that of other commonly used drugs in acute non-lymphocytic leukaemia, future studies should concentrate on other aspects, such as treatment of patients with steroid receptor-positive blast cells or other types of leukaemia.
摘要
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