Lugata John, Makower Laetitia, Rapheal Ashley, Maro Eusebious, Mremi Alex, Mchome Bariki
Department of Obstetrics and Gynecology, Kilimanjaro Christian Medical Centre, Moshi, Tanzania; Faculty of Medicine, Kilimanjaro Christian Medical University College, Moshi, Tanzania.
School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom.
Int J Surg Case Rep. 2025 Jan;126:110729. doi: 10.1016/j.ijscr.2024.110729. Epub 2024 Dec 10.
Adult-type granulosa cell tumors (AGCTs) are rare, low-grade malignant ovarian sex-cord stromal tumors, accounting for approximately 5 % of all ovarian tumors. These tumors are characterized by their potential for late recurrence and complex management, which presents significant challenges, particularly in resource-limited settings where access to advanced diagnostic tools and treatment options is restricted. This study highlights a series of rare AGCT cases diagnosed in premenopausal and postmenopausal women in Northern Tanzania. Given the global rarity of AGCTs and the limited literature on the condition, especially in this region, this study aims to address a critical knowledge gap.
This report presents a series of three patients diagnosed with ovarian adult-type granulosa cell tumors (AGCTs) based on histological findings. The series underscores the variability in clinical presentations and highlights the significance of individualized treatment approaches in managing these rare tumors.
Managing AGCTs in resource-limited settings requires balancing optimal care with available resources. Surgery remains the cornerstone of treatment; however, the lack of advanced diagnostic tools and limited access to adjuvant therapies necessitate a focus on achieving the best possible surgical outcomes and prioritizing rigorous clinical follow-up. This report explores the rarity of AGCTs, reviews existing literature on similar cases, and examines the numerous challenges associated with their management in such settings.
Adult granulosa cell tumors are rare, low-grade malignant neoplasms of the ovarian sex-cord stromal origin. These tumors are notable for their potential to recur even years after initial treatment. Consequently, regular follow-up with clinical examinations and tumor marker assessments is recommended. While chemotherapy can provide palliative benefits and manage recurrence, surgery remains the cornerstone of treatment, as illustrated in our case report.
成人型颗粒细胞瘤（AGCTs）是罕见的低级别恶性卵巢性索间质肿瘤，约占所有卵巢肿瘤的5%。这些肿瘤的特点是有晚期复发的可能性且管理复杂，这带来了重大挑战，尤其是在资源有限的环境中，获取先进诊断工具和治疗选择受到限制。本研究重点介绍了在坦桑尼亚北部绝经前和绝经后妇女中诊断出的一系列罕见AGCT病例。鉴于AGCTs在全球范围内的罕见性以及关于该病症的文献有限，特别是在该地区，本研究旨在填补关键的知识空白。
本报告呈现了基于组织学检查结果诊断为卵巢成人型颗粒细胞瘤（AGCTs）的三名患者。该系列强调了临床表现的多样性，并突出了个体化治疗方法在管理这些罕见肿瘤中的重要性。
在资源有限的环境中管理AGCTs需要在最佳护理与可用资源之间取得平衡。手术仍然是治疗的基石；然而，缺乏先进的诊断工具以及辅助治疗的获取有限，这就需要专注于实现尽可能好的手术结果，并优先进行严格的临床随访。本报告探讨了AGCTs的罕见性，回顾了关于类似病例的现有文献，并研究了在这种环境下管理它们所面临的众多挑战。
成人颗粒细胞瘤是起源于卵巢性索间质的罕见低级别恶性肿瘤。这些肿瘤值得注意的是即使在初始治疗数年之后仍有复发的可能性。因此，建议定期进行临床检查和肿瘤标志物评估随访。虽然化疗可以提供姑息性益处并控制复发，但如我们的病例报告所示，手术仍然是治疗的基石。
