慢性疼痛：一个可改变的降低围手术期心血管发病率的靶点。
Chronic pain: a modifiable target to reduce perioperative cardiovascular morbidity.
作者信息
Sikandar Shafaq, Ackland Gareth L
机构信息
Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, UK.
Translational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary University of London, London, UK.
出版信息
Br J Anaesth. 2025 Mar;134(3):627-631. doi: 10.1016/j.bja.2024.11.019. Epub 2024 Dec 12.
Abstract
Recent epidemiological studies suggest that chronic pain is a clinically under-recognised cause for cardiovascular morbidity and mortality. Up to 30% of patients undergoing surgery report chronic pain, but the impact of pre-existing pain on postoperative cardiovascular outcomes is not known. Chronic pain and cardiovascular dysfunction share fundamental pathological mechanisms. Chronic pain is a modifiable risk factor for perioperative cardiovascular morbidity.
摘要
近期的流行病学研究表明，慢性疼痛是心血管发病率和死亡率的一个临床上未得到充分认识的原因。高达30%接受手术的患者报告有慢性疼痛，但术前存在的疼痛对术后心血管结局的影响尚不清楚。慢性疼痛和心血管功能障碍有共同的基本病理机制。慢性疼痛是围手术期心血管发病的一个可改变的危险因素。
相似文献
1
Chronic pain: a modifiable target to reduce perioperative cardiovascular morbidity.慢性疼痛：一个可改变的降低围手术期心血管发病率的靶点。
Br J Anaesth. 2025 Mar;134(3):627-631. doi: 10.1016/j.bja.2024.11.019. Epub 2024 Dec 12.
2
Effects of perioperative statins on patient outcomes after noncardiac surgery: a meta-analysis.围手术期他汀类药物对非心脏手术后患者结局的影响：一项荟萃分析。
Ann Med. 2018 Aug;50(5):402-409. doi: 10.1080/07853890.2018.1471217. Epub 2018 May 15.
3
Perioperative Cardiac Risk Reduction in Noncardiac Surgery.非心脏手术的围手术期心脏风险降低。
Mayo Clin Proc. 2021 Aug;96(8):2260-2276. doi: 10.1016/j.mayocp.2021.03.014. Epub 2021 Jul 3.
4
Perioperative statin therapy for improving outcomes during and after noncardiac vascular surgery.围手术期他汀类药物治疗以改善非心脏血管手术期间及术后的结局。
Cochrane Database Syst Rev. 2013 Jul 3;2013(7):CD009971. doi: 10.1002/14651858.CD009971.pub2.
5
Perioperative beta blockade in noncardiac surgery: a systematic review for the 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines.非心脏手术中的围手术期β受体阻滞剂：2014 年 ACC/AHA 非心脏手术围手术期心血管评估和管理指南的系统评价：美国心脏病学会/美国心脏协会实践指南工作组的报告。
Circulation. 2014 Dec 9;130(24):2246-64. doi: 10.1161/CIR.0000000000000104. Epub 2014 Aug 1.
6
Association of Perioperative Statin Use With Mortality and Morbidity After Major Noncardiac Surgery.围手术期他汀类药物的使用与非心脏大手术后的死亡率和发病率的关系。
JAMA Intern Med. 2017 Feb 1;177(2):231-242. doi: 10.1001/jamainternmed.2016.8005.
7
Is perioperative beta-blockade effective and safe in patients undergoing noncardiac surgery?围手术期β受体阻滞剂对接受非心脏手术的患者是否有效且安全？
Medwave. 2016 Dec 27;16(Suppl5):e6819. doi: 10.5867/medwave.2016.6819.
8
Perioperative cardiovascular care for patients undergoing noncardiac surgical intervention.非心脏手术患者的围手术期心血管护理。
JAMA Intern Med. 2015 May;175(5):835-9. doi: 10.1001/jamainternmed.2015.0150.
9
Perioperative pharmacotherapy to prevent cardiac complications in patients undergoing noncardiac surgery.非心脏手术患者心脏并发症的围手术期药物治疗。
Expert Opin Pharmacother. 2021 Apr;22(6):755-767. doi: 10.1080/14656566.2020.1856368. Epub 2020 Dec 31.
10
A review of perioperative statin therapy for noncardiac surgery.非心脏手术围手术期他汀类药物治疗的综述
Semin Cardiothorac Vasc Anesth. 2010 Dec;14(4):283-90. doi: 10.1177/1089253210386387. Epub 2010 Nov 1.
本文引用的文献
1
Chronic pain in multiple sites is associated with cardiovascular dysfunction: an observational UK Biobank cohort study.多部位慢性疼痛与心血管功能障碍相关：一项基于英国生物库队列研究的观察性研究。
Br J Anaesth. 2024 Sep;133(3):605-614. doi: 10.1016/j.bja.2024.06.021. Epub 2024 Jul 14.
2
Multisite Pain and Myocardial Infarction and Stroke: A Prospective Cohort and Mendelian Randomization Analysis.多部位疼痛与心肌梗死和中风：一项前瞻性队列研究和孟德尔随机化分析
JACC Adv. 2023 Apr 26;2(3):100295. doi: 10.1016/j.jacadv.2023.100295. eCollection 2023 May.
3
Stress and cardiovascular disease: an update.压力与心血管疾病：最新研究进展。
Nat Rev Cardiol. 2024 Sep;21(9):603-616. doi: 10.1038/s41569-024-01024-y. Epub 2024 May 2.
4
Novel therapeutic targets and emerging treatments for atherosclerotic cardiovascular disease.动脉粥样硬化性心血管疾病的新型治疗靶点与新兴治疗方法
Eur Heart J Cardiovasc Pharmacother. 2024 Jan 5;10(1):53-67. doi: 10.1093/ehjcvp/pvad074.
5
One-year Outcomes after Discharge from Noncardiac Surgery and Association between Predischarge Complications and Death after Discharge: Analysis of the VISION Prospective Cohort Study.非心脏手术后出院一年的结局以及出院前并发症与出院后死亡之间的关联：VISION前瞻性队列研究分析
Anesthesiology. 2024 Jan 1;140(1):8-24. doi: 10.1097/ALN.0000000000004763.
6
Prevalence of chronic pain and chronic widespread pain among subjects with heart failure in the general population: The HUNT study.一般人群中心力衰竭患者慢性疼痛和广泛慢性疼痛的患病率：HUNT 研究。
Eur J Pain. 2024 Feb;28(2):273-284. doi: 10.1002/ejp.2176. Epub 2023 Sep 7.
7
Genetic liability to multi-site chronic pain increases the risk of cardiovascular disease.遗传易感性增加多部位慢性疼痛患者发生心血管疾病的风险。
Br J Anaesth. 2023 Aug;131(2):373-384. doi: 10.1016/j.bja.2023.04.020. Epub 2023 May 23.
8
Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia.中性粒细胞浸润感觉神经节并介导纤维肌痛的慢性广泛性疼痛。
Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2211631120. doi: 10.1073/pnas.2211631120. Epub 2023 Apr 18.
9
Contribution of microvascular dysfunction to chronic pain.微血管功能障碍对慢性疼痛的影响。
Front Pain Res (Lausanne). 2023 Feb 2;4:1111559. doi: 10.3389/fpain.2023.1111559. eCollection 2023.
10
A Shared Genetic Signature for Common Chronic Pain Conditions and its Impact on Biopsychosocial Traits.常见慢性疼痛病症的共享遗传特征及其对生物心理社会特征的影响。
J Pain. 2023 Mar;24(3):369-386. doi: 10.1016/j.jpain.2022.10.005. Epub 2022 Oct 14.
Zotero 插件