Luo Pengfei, He Jialiu, Wan Xinglin, Li Mengxia, Zhu Zheng, Chen Lulu, Hang Dong, Su Jian, Tao Ran, Zhou Jinyi, Fan Xikang
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
Department of Epidemiology and Biostatistics, Southeast University School of Public Health, Nanjing, Jiangsu, China.
BMJ Open Respir Res. 2024 Dec 12;11(1):e002366. doi: 10.1136/bmjresp-2024-002366.
Birth weight has been reported to be associated with chronic obstructive pulmonary disease (COPD) in adulthood, but the results have not yet been determined. This study aims to analyse the potential association of birth weight with COPD risk in UK Biobank.
We conducted a prospective analysis for participants without baseline COPD in UK Biobank. The HRs and 95% CIs were calculated by multivariable Cox regression models, and dose-response relationship was evaluated by restricted cubic splines. Besides, we also calculated the interactions for covariates and further analysed the joint effects.
A total of 251 172 participants with birth weight data were included in this study, and 5602 COPD cases were found during follow-up. According to Cox regression models, participants with the lowest quintile of birth weight (< 2.86 kg) had higher risk for COPD (HR=1.21, 95% CI 1.11 to 1.32). In addition, the dose‒response analysis showed a non-linear relationship between birth weight and COPD risk, which first decreased and then increased, and the interactions for age, passive smoking and maternal smoking were also found by stratified analysis. Furthermore, we also found the joint effects between COPD risk and maternal smoking in the lowest quintile group.
This study indicated that lower birth weight may increase the risk of COPD. The non-linear associations between birth weight and COPD risk for prospective cohort; as birth weight increased, the risk showed a trend of decreasing first and then increasing. Moreover, maternal smoking had a joint effect with low birth weight for COPD risk.
据报道，出生体重与成年期慢性阻塞性肺疾病（COPD）有关，但结果尚未确定。本研究旨在分析英国生物银行中出生体重与COPD风险之间的潜在关联。
我们对英国生物银行中无基线COPD的参与者进行了前瞻性分析。通过多变量Cox回归模型计算风险比（HRs）和95%置信区间（CIs），并通过限制性立方样条评估剂量反应关系。此外，我们还计算了协变量的相互作用，并进一步分析了联合效应。
本研究共纳入251172名有出生体重数据的参与者，随访期间发现5602例COPD病例。根据Cox回归模型，出生体重处于最低五分位数（<2.86 kg）的参与者患COPD的风险更高（HR=1.21，95%CI 1.11至1.32）。此外，剂量反应分析显示出生体重与COPD风险之间存在非线性关系，先下降后上升，分层分析还发现了年龄、被动吸烟和母亲吸烟的相互作用。此外，我们还在最低五分位数组中发现了COPD风险与母亲吸烟之间的联合效应。
本研究表明，较低的出生体重可能会增加患COPD的风险。前瞻性队列中出生体重与COPD风险之间存在非线性关联；随着出生体重的增加，风险呈先下降后上升的趋势。此外，母亲吸烟与低出生体重对COPD风险有联合作用。
