Hoshaw R A, Zimmerman K G, Menter A
Arch Dermatol. 1985 Jan;121(1):105-8.
Two patients had pitch-black pigmentation and colloid milium formation following the use of 2% hydroquinone-containing bleaching creams. These are among the first known cases in American blacks, although this phenomenon has been recognized previously in African blacks. Ultrastructural studies indicated that the pigment was due to the formation of elastotic fibers. These fibers attained an enormous size and disintegrated, leaving irregular fibers and fragments dispersed in the dermis. It is important that this clinical picture be recognized, since the use of these bleaching creams is widespread.
两名患者在使用含2%对苯二酚的美白霜后出现了深黑色色素沉着和胶样粟丘疹形成。这是美国黑人中首批已知的此类病例，尽管此前在非洲黑人中已认识到这种现象。超微结构研究表明，色素沉着是由于弹性纤维的形成。这些纤维变得非常粗大并解体，留下不规则的纤维和碎片散布在真皮中。鉴于这些美白霜的使用很普遍，认识到这种临床症状很重要。
