Bertario L, Reduzzi D, Piromalli D, Piva L, Di Pietro S
Ann Surg. 1985 Jan;201(1):64-7.
From 1948 to 1975, at the Istituto Nazionale Tumori of Milan, 209 patients underwent extended radical mastectomy (ERM) for breast cancer classified as T1 NO-1 MO. In 57 patients (27.3%), the ERM was preceded by an excisional biopsy performed in the outpatient clinic (Group A), of which 75% were performed within 30 days of admission and 25% after 30 days (average, 25 days; range 5-99). The remaining 152 patients (Group B) underwent an extemporaneous frozen biopsy. There was no difference in the distribution of the histologic types in the two groups. The axillary lymph nodes (N) and the internal mammary chain (MI) were free of neoplastic invasion (N-, MI-) in 156 patients (74.6%), 44 in Group A (77.2%) and 112 in Group B (73.7%). Actuarial 10-year survival of the patients was 79.9% in Group A and 77.7% in Group B (p = NS). It was 90% in N- MI- patients of Group A and 81.9% in those of Group B (p = NS). Instead, for N+ patients, actuarial survival at 10 years was 50% in Group A and 67% in Group B (p = NS), and for MI+ patients it was 50% and 49.8%, respectively. These present data do not support the hypothesis that a delay between biopsy and radical surgery of breast cancer is an important prognostic factor.
1948年至1975年期间，在米兰国立肿瘤研究所，209例被分类为T1 NO-1 MO的乳腺癌患者接受了扩大根治性乳房切除术（ERM）。57例患者（27.3%）在ERM之前在门诊进行了切除活检（A组），其中75%在入院后30天内进行，25%在30天后进行（平均25天；范围5 - 99天）。其余152例患者（B组）接受了术中冰冻活检。两组的组织学类型分布没有差异。156例患者（74.6%）的腋窝淋巴结（N）和内乳链（MI）无肿瘤侵犯（N-，MI-），A组44例（77.2%），B组112例（73.7%）。A组患者的10年精算生存率为79.9%，B组为77.7%（p = 无统计学意义）。A组N- MI-患者的10年精算生存率为90%，B组为81.9%（p = 无统计学意义）。相反，对于N+患者，A组10年精算生存率为50%，B组为67%（p = 无统计学意义），对于MI+患者，分别为50%和49.8%。目前这些数据不支持乳腺癌活检与根治性手术之间的延迟是一个重要预后因素的假设。
