Chen Wen, Chen Songhao, Zhao Xiaoyu, Yang Lan, Zhao Yunbiao, Wei Ruihua, Wu Jinfang
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin 300384, China.
Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing 100871, China.
ACS Sens. 2025 Feb 28;10(2):814-824. doi: 10.1021/acssensors.4c02361. Epub 2024 Dec 12.
Eyelid pressure is a crucial biomechanical parameter for ocular health and refractive status, yet measuring it poses challenges related to flexibility, sensitivity, and regional specificity. This study introduces a novel smart contact lens that incorporates kirigami designs and an iontronic capacitive sensing array to enhance flexibility and conformability. The unique structural composition of this device allows for precise and simultaneous monitoring of eyelid pressure in multiple regions with a high sensitivity and seamlessly fit across corneal curvatures. The efficacy of the sensor has been thoroughly confirmed through comprehensive evaluations in rabbits and porcine eyes, demonstrating improved conformity and sensitivity compared to conventional single-point sensors. Assessments have been conducted in various conditions, including under anesthesia and in awake states, as well as the deliberate alteration of intraocular pressure fluctuations, all affirming the exceptional accuracy in detecting eyelid pressure. We envision that the smart contact lens has the potential to revolutionize diagnosis and management of eyelid-related ocular diseases.
眼睑压力是影响眼部健康和屈光状态的关键生物力学参数，但测量眼睑压力在灵活性、灵敏度和区域特异性方面存在挑战。本研究介绍了一种新型智能隐形眼镜，它采用了剪纸设计和离子电子电容传感阵列，以提高灵活性和贴合度。该设备独特的结构组成允许在多个区域精确同时监测眼睑压力，具有高灵敏度，并能无缝贴合不同的角膜曲率。通过在兔眼和猪眼中进行的全面评估，充分证实了该传感器的功效，与传统单点传感器相比，其贴合度和灵敏度都有所提高。评估在各种条件下进行，包括麻醉状态和清醒状态，以及故意改变眼压波动，所有这些都证实了该传感器在检测眼睑压力方面具有极高的准确性。我们设想，这种智能隐形眼镜有可能彻底改变与眼睑相关的眼部疾病的诊断和管理方式。
