Klingbeil G E, Cline P
Arch Phys Med Rehabil. 1985 Jan;66(1):44-6.
Anterior pituitary insufficiency in patients with traumatic brain injury is rare. Only sporadic cases have been reported in the literature. The authors report a case of panhypopituitarism that developed in a 19-year-old man and was diagnosed six months after the patient sustained severe craniocerebral trauma in a motor vehicle accident. After an initial slow improvement in neurologic function he very gradually retrogressed in physical and mental capacities. An acute adrenal crisis led to the diagnosis of hypopituitarism. Institution of appropriate hormone therapy resulted in steady improvement in motor and cognitive functioning. The authors reviewed the literature and discuss the possible pathophysiology. They exhort physiatrists to be aware of this rare but potentially fatal consequence of craniocerebral trauma.
创伤性脑损伤患者发生垂体前叶功能减退较为罕见。文献中仅报道过散发病例。作者报告了一例全垂体功能减退症，该病例发生在一名19岁男性身上，患者在机动车事故中遭受严重颅脑创伤6个月后被诊断出此病。在神经功能最初缓慢改善后，他的身心能力逐渐衰退。一次急性肾上腺危象导致了垂体功能减退的诊断。给予适当的激素治疗后，运动和认知功能稳步改善。作者回顾了文献并讨论了可能的病理生理学。他们告诫物理治疗师要意识到这种颅脑创伤罕见但可能致命的后果。
