Xu Li, Li Jiayang, Wu Wenqi, Wu Xiuwen, Ren Jianan
Research Institute of General Surgery, Jinling Hospital, the Affiliated Hospital of Medical School, Nanjing Medical University, Nanjing, China.
Research Institute of General Surgery, Jinling Hospital, the Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Virulence. 2024 Dec;15(1):2439509. doi: 10.1080/21505594.2024.2439509. Epub 2024 Dec 13.
Hypervirulent exhibits strong pathogenicity and can cause severe invasive infections but is historically recognized as antibiotic-susceptible. In recent years, the escalating global prevalence of antibiotic-resistant hypervirulent has raised substantial concerns and created an urgent demand for effective treatment options. Capsular polysaccharide (CPS) is one of the main virulence determinants contributing to the hypervirulent phenotype. The structure of CPS varies widely among strains, and both the structure and composition of CPS can influence the virulence of . CPS possesses various immune evasion mechanisms that promote the survival of , as well as its colonization and dissemination. Given the proven viability of therapies that target the capsule, improving our understanding of the CPS structure is critical to effectively directing treatment strategies. In this review, the structure and typing of CPS are addressed as well as genes related to synthesis and regulation, relationships with virulence, and pathogenic mechanisms. We aim to provide a reference for research on the pathogenesis of .
高毒力菌株表现出很强的致病性，可引起严重的侵袭性感染，但在历史上被认为对抗生素敏感。近年来，全球范围内对抗生素耐药的高毒力菌株的流行不断升级，引发了人们的极大关注，并迫切需要有效的治疗方案。荚膜多糖（CPS）是导致高毒力表型的主要毒力决定因素之一。CPS的结构在不同菌株间差异很大，其结构和组成都可影响菌株的毒力。CPS具有多种免疫逃避机制，可促进菌株的存活及其定植和传播。鉴于靶向荚膜的治疗方法已被证明可行，加深我们对CPS结构的理解对于有效指导治疗策略至关重要。在本综述中，将探讨CPS的结构和分型，以及与合成和调控相关的基因、与毒力的关系和致病机制。我们旨在为该菌株致病机制的研究提供参考。
