视神经脊髓炎谱系疾病（MOGAD）患者的爱泼斯坦-巴尔病毒感染
Epstein-Barr virus infection in patients with MOGAD.
作者信息
Maniscalco Giorgia T, Dinoto Alessandro, Foglia Maria C, Di Battista Maria E, Moreggia Ornella, Di Giulio Cesare Daniele, Williams Michela, Rossi Francesca W, Carta Sara, Chiodega Vanessa, Ferrari Sergio, Viola Assunta, de Paulis Amato, Andreone Vincenzo, Mariotto Sara
机构信息
Neurological Clinic and Stroke Unit, Multiple Sclerosis Regional Center, "A. Cardarelli" Hospital, Naples, Italy.
Multiple Sclerosis and Neuroimmunology Center, "A. Cardarelli" Hospital, Naples, Italy.
出版信息
Mult Scler. 2025 Jan;31(1):117-120. doi: 10.1177/13524585241298065. Epub 2024 Dec 13.
BACKGROUND
Epstein-Barr virus (EBV) infection increases the risk of having multiple sclerosis (MS). Data on adults with myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are lacking.
OBJECTIVE
To compare EBV serological status in MOGAD versus MS.
METHODS
We measured antibodies to Epstein-Barr nuclear antigen (EBNA-1) and viral capsid antigen (VCA) antigens in 129 patients (MS = 74, MOGAD = 55) by chemiluminescence immunoassays.
RESULTS
VCA-IgG were detected in 97.3% of MS and 96.4% of MOGAD cases, while EBNA-1-IgG in 97.3% of MS and 80% of MOGAD ( = 0.001). EBNA-1 ( < 0.001) and VCA ( = 0.03) antibodies levels were higher in MS patients.
CONCLUSION
EBV antibodies are higher in MS versus MOGAD, suggesting a possible different role of EBV in the pathogenesis of the two conditions.
背景
爱泼斯坦-巴尔病毒（EBV）感染会增加患多发性硬化症（MS）的风险。目前缺乏关于成人髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）的数据。
目的
比较MOGAD与MS患者的EBV血清学状态。
方法
我们通过化学发光免疫分析法检测了129例患者（MS患者74例，MOGAD患者55例）的抗爱泼斯坦-巴尔核抗原（EBNA-1）和病毒衣壳抗原（VCA）抗体。
结果
97.3%的MS患者和96.4%的MOGAD患者检测到VCA-IgG，而97.3%的MS患者和80%的MOGAD患者检测到EBNA-1-IgG（P = 0.001）。MS患者的EBNA-1（P < 0.001）和VCA（P = 0.03）抗体水平更高。
结论
MS患者的EBV抗体水平高于MOGAD患者，提示EBV在这两种疾病发病机制中可能发挥不同作用。
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