• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

卡介苗在肺癌切除术后作为免疫刺激剂的应用:对500例患者进行的一项试验的两年评估。

Use of BCG as an immunostimulant after resection of carcinoma of the lung: a two-year assessment of a trial of 500 patients.

作者信息

Edwards F R

出版信息

Thorax. 1979 Dec;34(6):801-6. doi: 10.1136/thx.34.6.801.

DOI:10.1136/thx.34.6.801
PMID:396688
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC471200/
Abstract

BCG (Glaxo) (0.5 ml = 5 X 10(6) organisms) was given subdermally to 250 patients ten days after resection of a lung carcinoma to stimulate the immune system. Increased activity of lymphocytes and macrophages could possibly result in the destruction of small extrapulmonary tumour deposits that were previously unidentified. The two-year survival of this group of patients was compared with 250 controls not receiving BCG after operation. A comparative analysis of the sex, histological types, and lymph node involvement in relation to the survivals occurring in these two groups showed that the administration of BCG by the method described produced a numerically greater survival rate, which was particularly noticeable in the women. None of these figures, however, is statistically significant. It would be unwise to draw any final conclusion until a five-year survey has been completed.

摘要

卡介苗(葛兰素公司生产)(0.5毫升 = 5×10⁶个菌体)在肺癌切除术后十天皮下注射给250名患者,以刺激免疫系统。淋巴细胞和巨噬细胞活性的增强可能导致此前未被发现的肺外小肿瘤沉积物的破坏。将这组患者的两年生存率与250名术后未接受卡介苗的对照组进行比较。对这两组患者生存情况相关的性别、组织学类型和淋巴结受累情况进行的对比分析表明,按所述方法给予卡介苗后,从数字上看生存率更高,在女性中尤为明显。然而,这些数字均无统计学意义。在完成五年调查之前得出任何最终结论都是不明智的。

相似文献

1
Use of BCG as an immunostimulant after resection of carcinoma of the lung: a two-year assessment of a trial of 500 patients.卡介苗在肺癌切除术后作为免疫刺激剂的应用:对500例患者进行的一项试验的两年评估。
Thorax. 1979 Dec;34(6):801-6. doi: 10.1136/thx.34.6.801.
2
Five-year results of a controlled study of BCG immunotherapy after surgical resection in bronchogenic carcinoma.支气管源性癌手术切除后卡介苗免疫治疗对照研究的五年结果
Thorax. 1982 Jan;37(1):57-60. doi: 10.1136/thx.37.1.57.
3
Use of BCG as an immunostimulant in the surgical treatment of carcinoma of lung: a five-year follow-up report.卡介苗作为免疫刺激剂在肺癌外科治疗中的应用:五年随访报告。
Thorax. 1978 Apr;33(2):250-2. doi: 10.1136/thx.33.2.250.
4
[The use of BCG vaccine for preventing recurrences of superficial bladder cancer].
Urol Nefrol (Mosk). 1996 Mar-Apr(2):23-5.
5
Adjuvant immunotherapy with BCG in treatment of regional-lymph-node metastases from malignant melanoma.卡介苗辅助免疫疗法治疗恶性黑色素瘤区域淋巴结转移
N Engl J Med. 1976 Jan 29;294(5):237-40. doi: 10.1056/NEJM197601292940501.
6
Oral administration of BCG as an adjuvant to surgical treatment of carcinoma of the bronchus.口服卡介苗作为支气管癌手术治疗的辅助手段。
Can Med Assoc J. 1979 Jul 7;121(1):45-54.
7
Use of BCG as an immunostimulant in the surgical treatment of carcinoma of the lung.卡介苗作为免疫刺激剂在肺癌手术治疗中的应用。
Thorax. 1974 Nov;29(6):654-8. doi: 10.1136/thx.29.6.654.
8
BCG as adjuvant immunotherapy for neoplasia.卡介苗作为肿瘤的辅助免疫疗法。
Annu Rev Med. 1977;28:489-515. doi: 10.1146/annurev.me.28.020177.002421.
9
A stratified randomized study of intradermal BCG in patients with carcinoma of the bronchus: prolongation of quality but not length of life in inoperable patients.支气管癌患者皮内注射卡介苗的分层随机研究:不可手术患者生活质量延长但生存期未延长
Cancer. 1978 Oct;42(4):1784-92. doi: 10.1002/1097-0142(197810)42:4<1784::aid-cncr2820420417>3.0.co;2-m.
10
Adjuvant BCG immunotherapy for malignant melanoma.恶性黑色素瘤的辅助卡介苗免疫疗法。
Can Med Assoc J. 1984 Oct 1;131(7):744-8.

引用本文的文献

1
Immunotherapy in lung cancer.肺癌中的免疫疗法。
Br J Cancer. 1998 Aug;78(3):282-8. doi: 10.1038/bjc.1998.486.
2
The role of post-operative radiotherapy in non-small-cell lung cancer: a multicentre randomised trial in patients with pathologically staged T1-2, N1-2, M0 disease. Medical Research Council Lung Cancer Working Party.术后放疗在非小细胞肺癌中的作用:一项针对病理分期为T1-2、N1-2、M0疾病患者的多中心随机试验。医学研究委员会肺癌工作组
Br J Cancer. 1996 Aug;74(4):632-9. doi: 10.1038/bjc.1996.413.
3
Postoperative intrapleural BCG in lung cancer: lack of efficacy and possible enhancement of tumour growth.肺癌术后胸膜腔内注射卡介苗:缺乏疗效且可能促进肿瘤生长。
Thorax. 1981 Nov;36(11):870-4. doi: 10.1136/thx.36.11.870.
4
Five-year results of a controlled study of BCG immunotherapy after surgical resection in bronchogenic carcinoma.支气管源性癌手术切除后卡介苗免疫治疗对照研究的五年结果
Thorax. 1982 Jan;37(1):57-60. doi: 10.1136/thx.37.1.57.

本文引用的文献

1
Effect of Bacillus Calmette-Guerin infection on transplanted tumours in the mouse.卡介苗感染对小鼠移植瘤的影响。
Nature. 1959 Jul 25;184(Suppl 5):291-2. doi: 10.1038/184291a0.
2
IMMUNOLOGIC AND CYTOGENETIC STUDIES OF CHRONIC LYMPHOCYTIC LEUKEMIC CELLS.慢性淋巴细胞白血病细胞的免疫学和细胞遗传学研究
Blood. 1965 Aug;26:121-32.
3
[Estrogens and phagocytic function of the reticuloendothelial system].[雌激素与网状内皮系统的吞噬功能]
C R Seances Soc Biol Fil. 1957;151(7):1326-31.
4
Stimulation of host defense against experimental cancer. I. Zymosan and sarcoma 180 in mice.增强宿主对实验性癌症的防御。I. 酵母聚糖与小鼠肉瘤180
Cancer Res. 1958 Apr;18(3):347-51.
5
Inhibition of tumour growth by administration of killed corynebacterium parvum.通过给予灭活的短小棒状杆菌抑制肿瘤生长。
Nature. 1966 Nov 19;212(5064):853-4. doi: 10.1038/212853a0.
6
Use of BCG as an immunostimulant in the surgical treatment of carcinoma of the lung.卡介苗作为免疫刺激剂在肺癌手术治疗中的应用。
Thorax. 1974 Nov;29(6):654-8. doi: 10.1136/thx.29.6.654.
7
Use of BCG as an immunostimulant in the surgical treatment of carcinoma of lung: a five-year follow-up report.卡介苗作为免疫刺激剂在肺癌外科治疗中的应用:五年随访报告。
Thorax. 1978 Apr;33(2):250-2. doi: 10.1136/thx.33.2.250.