肺对14C-普萘洛尔的首过摄取。
First pass uptake of 14C-propranolol by the lung.
作者信息
Geddes D M, Nesbitt K, Traill T, Blackburn J P
出版信息
Thorax. 1979 Dec;34(6):810-3. doi: 10.1136/thx.34.6.810.
Abstract
Uptake of 14C-propranolol by the lungs during a single passage through the pulmonary circulation was measured in ten patients at cardiac catheterisation. Mean lung uptake of propranolol was 75% in seven patients who were not previously taking the drug and 33% in three patients who were taking it as regular oral treatment. Lung uptake of propranolol in man is therefore considerable and is partly saturable by normal oral doses. This may alter the dose response relation for propranolol and a wide range of other drugs when given intravenously. The method used to study lung uptake is simple and might be suitable for studies of endothelial cell function in disease.
摘要
在十名接受心导管检查的患者中，测量了14C-普萘洛尔单次通过肺循环时肺对其的摄取情况。七名此前未服用该药物的患者中，普萘洛尔的平均肺摄取率为75%，三名接受常规口服治疗的患者中该摄取率为33%。因此，人肺对普萘洛尔的摄取相当可观，且可被正常口服剂量部分饱和。这可能会改变静脉注射普萘洛尔及众多其他药物时的剂量反应关系。用于研究肺摄取的方法简单，可能适用于疾病状态下内皮细胞功能的研究。
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