Pang J A, Williams T R, Blackburn J P, Butland R J, Geddes D M
Br J Anaesth. 1981 Jun;53(6):601-4. doi: 10.1093/bja/53.6.601.
Uptake of 14C-propranolol after a single passage through the pulmonary circulation was studied in three groups of Labrador dogs using a double indicator dilution method. Uptake in conscious, ambulant animals was 53%. This increased to 81% in dogs anaesthetized with thiopentone, nitrous oxide and halothane and to 64% in dogs anaesthetized with thiopentone, nitrous oxide and fentanyl. Interaction between lipid-soluble anaesthetic agents and pulmonary endothelial cell membranes may be an important factor in increasing lung uptake of lipophilic propranolol, although alteration in pulmonary perfusion associated with a reduction in cardiac output during general anaesthesia may play a part. The pharmacological effects of propranolol administered i.v. during general anaesthesia may be unpredictable.
使用双指示剂稀释法，在三组拉布拉多犬中研究了14C-普萘洛尔单次通过肺循环后的摄取情况。清醒、活动的动物摄取率为53%。用硫喷妥钠、氧化亚氮和氟烷麻醉的犬摄取率增至81%，用硫喷妥钠、氧化亚氮和芬太尼麻醉的犬摄取率增至64%。脂溶性麻醉剂与肺内皮细胞膜之间的相互作用可能是增加亲脂性普萘洛尔肺摄取的一个重要因素，尽管全身麻醉期间与心输出量减少相关的肺灌注改变可能也起一定作用。全身麻醉期间静脉注射普萘洛尔的药理作用可能无法预测。
