Franciscatto Maria Elisa, Taniguchi Juliana Bosso, Wohlenberg Raquel, Riedi Isadora Luísa, Oppermann Karen
Universidade de Passo Fundo Faculty of Medicine Passo FundoRS Brazil Faculty of Medicine, Universidade de Passo Fundo, Passo Fundo, RS, Brazil.
Hospital São Vicente de Paulo Gynecology and Obstetrics Passo FundoRS Brazil Gynecology and Obstetrics, Hospital São Vicente de Paulo, Passo Fundo, RS, Brazil.
Rev Bras Ginecol Obstet. 2024 Dec 4;46. doi: 10.61622/rbgo/2024rbgo81. eCollection 2024.
To verify the prevalence and factors associated with Non-Alcoholic Fatty Liver Disease (NAFLD) among women with Polycystic Ovary Syndrome (PCOS).
A cross-sectional study was conducted with 53 patients with PCOS. The diagnosis of PCOS followed the Rotterdam criteria. The diagnosis of NAFLD was made through US showing hepatic steatosis, excluding significant alcohol consumption and chronic liver disease. The following variables were compared between the groups of women with and without NAFLD: age, race, anthropometric data, blood pressure levels, liver enzymes, glycemic and lipid profiles, total testosterone, presence of hirsutism, and metabolic syndrome (MS). Variables were compared between the groups using T-test, Mann-Whitney, and Chi-square tests.
Among 53 patients with PCOS, 50.9% had NAFLD. The NAFLD group had higher weight (p=0.003), BMI (p=0.001), waist circumference (p≤0.001), fasting glucose (p=0.021), HbA1C% (p=0.028), triglycerides (p=0.023), AST (p=0.004), ALT (p=0.001), higher prevalence of MS (p=0.004), and lower levels of HDL cholesterol (p=0.043). The other variables did not differ between the groups. Both groups were predominantly of caucasian race, and there was no significant difference in age.
The prevalence of NAFLD among patients with PCOS was 50.9%. Metabolic and hepatic enzyme abnormalities were more prevalent in this group compared to the group without the disease. Obesity tripled the prevalence of NAFLD.
验证多囊卵巢综合征（PCOS）女性中非酒精性脂肪性肝病（NAFLD）的患病率及相关因素。
对53例PCOS患者进行了一项横断面研究。PCOS的诊断遵循鹿特丹标准。NAFLD的诊断通过超声显示肝脂肪变性来确定，排除大量饮酒和慢性肝病。比较了有和没有NAFLD的女性组之间的以下变量：年龄、种族、人体测量数据、血压水平、肝酶、血糖和血脂谱、总睾酮、多毛症的存在情况以及代谢综合征（MS）。使用T检验、曼-惠特尼检验和卡方检验对两组之间的变量进行比较。
在53例PCOS患者中，50.9%患有NAFLD。NAFLD组的体重（p = 0.003）、BMI（p = 0.001）、腰围（p≤0.001）、空腹血糖（p = 0.021）、糖化血红蛋白百分比（p = 0.028）、甘油三酯（p = 0.023）、谷草转氨酶（p = 0.004）、谷丙转氨酶（p = 0.001）更高，MS的患病率更高（p = 0.004），高密度脂蛋白胆固醇水平更低（p = 0.043）。其他变量在两组之间没有差异。两组主要为白种人，年龄没有显著差异。
PCOS患者中NAFLD的患病率为50.9%。与无该疾病的组相比，该组中代谢和肝酶异常更为普遍。肥胖使NAFLD的患病率增加了两倍。
