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患有先天性尿崩症的儿童行颅咽管瘤切除术的围手术期管理:一例报告

Perioperative Management of a Child With Pre-existing Diabetes Insipidus Undergoing Craniopharyngioma Excision: A Case Report.

作者信息

Lakhe Prashant B, Kutum Chayanika, Sabu Nayana, Kewlani Anu, Sharma Ridhima

机构信息

Department of Neurosurgery, All India Institute of Medical Sciences, Nagpur, Nagpur, IND.

Department of Anaesthesiology, All India Institute of Medical Sciences, Nagpur, Nagpur, IND.

出版信息

Cureus. 2024 Nov 12;16(11):e73518. doi: 10.7759/cureus.73518. eCollection 2024 Nov.

Abstract

Craniopharyngiomas are rare tumors arising in the suprasellar area of the brain and are more common in the pediatric age group. Due to the involvement of the hypothalamus, central diabetes insipidus (DI) is usually associated with such lesions. Patients with DI are at risk for significant electrolyte disturbances due to high urine output and the potential for sodium imbalance. Perioperative management of a patient with co-existing DI is challenging due to the imbalances in the fluid and electrolyte status. We reported a rare case of successful intraoperative anesthetic management of a pediatric patient undergoing craniopharyngioma excision with pre-existing central DI. The main anesthetic concerns were intraoperative fluid and electrolyte disbalance, and further risk of hypothalamic damage with the possibility of seizure, hyperthermia, and hemodynamic instability. Intraoperatively, a meticulous fluid management strategy was employed, keeping a strict watch on urine output and serum electrolyte levels. Intraoperative DI was treated with low-dose vasopressin infusion. Intensive monitoring of the fluid and electrolyte status in a patient during craniopharyngioma surgery is of utmost importance. A proper collaborative team effort between the neurosurgeons, neuroanesthesiologists, and the neuroendocrine team is essential for a successful outcome.

摘要

颅咽管瘤是起源于脑鞍上区的罕见肿瘤,在儿童年龄组中更为常见。由于下丘脑受累,中枢性尿崩症(DI)通常与这类病变相关。患有尿崩症的患者因尿量增多和钠失衡的可能性而有发生严重电解质紊乱的风险。由于液体和电解质状态失衡,合并尿崩症患者的围手术期管理具有挑战性。我们报告了一例罕见病例,一名患有中枢性尿崩症的小儿患者在接受颅咽管瘤切除术中成功进行了麻醉管理。主要的麻醉关注点是术中液体和电解质失衡,以及下丘脑损伤的进一步风险,包括癫痫发作、体温过高和血流动力学不稳定的可能性。术中采用了细致的液体管理策略,密切监测尿量和血清电解质水平。术中尿崩症通过低剂量血管加压素输注进行治疗。在颅咽管瘤手术期间对患者的液体和电解质状态进行强化监测至关重要。神经外科医生、神经麻醉医生和神经内分泌团队之间适当的协作努力对于取得成功结果至关重要。

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