Rodrigues-Fernandes Carla Isabelly, Moura Anne Evelyn Oliveira, Farias Danielle Machado, Carvalho Elaine Judite de Amorim, Vargas Pablo Agustin, Perez Danyel Elias da Cruz
DDS, PhD. Oral Pathology Unit, Department of Clinic and Preventive Dentistry, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
DDS. Department of Oral Diagnosis, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
J Clin Exp Dent. 2024 Nov 1;16(11):e1429-e1432. doi: 10.4317/jced.62199. eCollection 2024 Nov.
Inverted ductal papilloma is an uncommon benign papillary endophytic tumor. This report aimed to present a case of inverted ductal papilloma of the oral cavity. A 54-year-old female patient presented with an asymptomatic nodular lesion on the lower lip. Time of duration was undetermined. The diagnostic hypotheses were fibrous hyperplasia and benign mesenchymal neoplasm. An excisional biopsy was performed, and microscopic examination showed an endophytic proliferation of squamous cells with the presence of microcysts, and goblet cells arranged in nest and islands. No cellular atypia was observed. The neoplastic cells were positive for CK7, and CK14. Proliferation index, demonstrated by Ki-67, was positively restricted to the basal tumor layer. The final diagnosis was oral inverted ductal papilloma. No signs of recurrence were found after surgery. Inverted papilloma, intraductal papilloma, oral papilloma.
内翻性导管乳头状瘤是一种罕见的良性乳头状内生性肿瘤。本报告旨在介绍一例口腔内翻性导管乳头状瘤病例。一名54岁女性患者下唇出现无症状结节性病变。病程时间不详。诊断假设为纤维增生和良性间叶性肿瘤。进行了切除活检，显微镜检查显示鳞状细胞内生性增生，伴有微囊肿，杯状细胞呈巢状和岛状排列。未观察到细胞异型性。肿瘤细胞CK7和CK14呈阳性。Ki-67显示的增殖指数阳性仅限于肿瘤基底层。最终诊断为口腔内翻性导管乳头状瘤。术后未发现复发迹象。内翻性乳头状瘤、导管内乳头状瘤、口腔乳头状瘤。
