Popov Iu V, Saprygin D B, Egorova I F, Kashtélian L S, Bakuleva N P
Biull Eksp Biol Med. 1985 Jan;99(1):108-10.
The protective effects of cardioplegic solutions (CS) containing creatine phosphate (CP) were studied in a rat heart model of cardiopulmonary bypass and ischemic cardiac arrest. Isolated rat hearts were subjected to a 3-minute coronary infusion with CS containing CP in normothermic (37 degrees C) and hypothermic (4-6 degrees C) regimes. In the normothermia group, the postischemic functional recovery was 70-75% of the preischemic control value, while the cellular ATP and CP content was reduced but insignificantly. By contrast, in the hypothermia group, the postischemic functional recovery was markedly depressed, with the tissue high-energy phosphate content being appreciably lowered. The data obtained confirm high efficacy of CP-containing cardioplegic solutions administered under normothermia conditions.
在大鼠体外循环和缺血性心脏骤停模型中，研究了含磷酸肌酸（CP）的心脏停搏液（CS）的保护作用。将离体大鼠心脏在常温（37℃）和低温（4 - 6℃）条件下用含CP的CS进行3分钟冠状动脉灌注。在常温组中，缺血后功能恢复为缺血前对照值的70 - 75%，而细胞ATP和CP含量降低但不显著。相比之下，在低温组中，缺血后功能恢复明显受抑，组织高能磷酸含量明显降低。所获数据证实了在常温条件下给予含CP心脏停搏液的高效性。
