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欧洲宫颈癌消除及人乳头瘤病毒(HPV)相关癌症预防的准备情况评估——我们在这场竞赛中获胜了吗?

Readiness assessment for cervical cancer elimination and prevention of human papillomavirus (HPV)-related cancers in Europe - are we winning the RACE?

作者信息

Karamousouli Eugenia, Sabale Ugne, Valente Stefano, Morosan Fanut, Heuser Maria, Dodd Olivia, Riley Danielle, Heron Louise, Calabrò Giovanna Elisa, Agorastos Theodoros, Sevelda Paul, Krasznai Zoárd Tibor, Nahum Shay, Horby Rune

机构信息

Regional Market Access, MSD, Athens, Greece.

Value & Implementation Outcomes Research, MSD, Vilnius, Lithuania.

出版信息

Expert Rev Vaccines. 2025 Dec;24(1):11-26. doi: 10.1080/14760584.2024.2438759. Epub 2024 Dec 15.

Abstract

INTRODUCTION

To address the cervical cancer burden globally, the World Health Organization and European Union released strategies to facilitate HPV-related cancers prevention, including cervical cancer elimination. This research assessed European country level readiness to achieve cervical cancer elimination by adhering to such strategies.

AREAS COVERED

Readiness for cervical cancer elimination was assessed across a range of guiding questions relevant to three defined key domains: vaccination, screening, and treatment, each with two sub-domains focusing on decision making and implementation efforts. Publicly available data sources were used to inform the scoring across domains, to tier countries into either high, moderate-high, moderate-low, and low readiness archetypes.Key parameters identified associated with the high readiness archetype were high vaccination coverage rates (>70%), availability of gender neutral and catch-up vaccination, school-based vaccination availability, organized screening programs, use of HPV DNA primary screening tests, and data surveillance.

EXPERT OPINION

Our analysis highlights significant variability in decision making and implementation of vaccination, screening, and treatment programmes across Europe. Country scores expose the need for a multifaceted approach to achieve cervical cancer elimination in Europe, encompassing solid decision making commitments, implementation of these commitments, and the ability to collect, surveil, and apply the data use accurately.

摘要

引言

为应对全球宫颈癌负担,世界卫生组织和欧盟发布了促进预防人乳头瘤病毒相关癌症(包括消除宫颈癌)的战略。本研究评估了欧洲国家层面通过遵循此类战略实现消除宫颈癌的准备情况。

涵盖领域

通过一系列与三个明确的关键领域相关的指导性问题评估消除宫颈癌的准备情况,这三个领域为:疫苗接种、筛查和治疗,每个领域有两个子领域,分别侧重于决策制定和实施工作。使用公开可用的数据源为各领域评分提供依据,将各国分为高、中高、中低和低准备就绪原型。确定与高准备就绪原型相关的关键参数为高疫苗接种覆盖率(>70%)、提供性别中立和补种疫苗、具备基于学校的疫苗接种、有组织的筛查计划、使用人乳头瘤病毒DNA初筛检测以及数据监测。

专家意见

我们的分析突出了欧洲在疫苗接种、筛查和治疗计划的决策制定和实施方面存在显著差异。各国得分表明,在欧洲实现消除宫颈癌需要采取多方面的方法,包括坚定的决策承诺、这些承诺的实施以及准确收集、监测和应用数据的能力。

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