将面孔与名字及饮食联系起来作为认知健康个体早期阿尔茨海默病的生物标志物。

Associating faces with names and meals as a biomarker of early AD in cognitively healthy individuals.

作者信息

Andrés Pilar, Flores-Vázquez Juan Francisco, Enriquez-Geppert Stefanie

机构信息

Neuropsychology and Cognition Research group, Department of Psychology, IUNICS, University of the Balearic Islands, and Health Research Institute of the Balearic Islands, (IdISBa), Palma de Mallorca, Spain.

Department of Clinical and Epidemiological Research, National Institute of Geriatrics, Mexico, Mexico.

出版信息

J Alzheimers Dis. 2024 Dec;102(3):639-641. doi: 10.1177/13872877241289613. Epub 2024 Oct 29.

DOI:10.1177/13872877241289613

PMID:39670734

Abstract

The Learning and Associative Memory (LAM) test is a face-name associative memory test created to detect early Alzheimer's disease (AD). In a recent study, it was administered to cognitively healthy individuals with different levels of amyloid-β (Aβ) and tau burden. The key findings for LAM were: 1) selective correlations with Aβ levels, 2) unique discriminatory power between A + and A- individuals, 3) significantly higher areas under the curve in receiver operating curve analysis. Future research should focus on comparing performance on the LAM and face-name associative memory tests to determine the most effective method for detecting early signs of AD.

摘要

学习与联想记忆（LAM）测试是一种为检测早期阿尔茨海默病（AD）而创建的面孔-名字联想记忆测试。在最近的一项研究中，该测试被应用于具有不同淀粉样蛋白-β（Aβ）和tau负荷水平的认知健康个体。LAM的主要发现为：1）与Aβ水平的选择性相关性；2）A+和A-个体之间独特的区分能力；3）在受试者工作特征曲线分析中曲线下面积显著更高。未来的研究应聚焦于比较LAM测试和面孔-名字联想记忆测试的表现，以确定检测AD早期迹象的最有效方法。