Baur Philipp, Comba Peter
Institute for Molecular Bioscience, The University of Queensland, 305 Carmondy Road, 4067 St Lucia, QLD, Australia.
Anorganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
Dalton Trans. 2025 Mar 4;54(10):3968-3976. doi: 10.1039/d4dt03002h.
, an obligate symbiont of certain ascidians (sea squirts found in tropical areas), produces various cyclic pseudo-octapeptides in large quantities. These secondary metabolites have attracted the attention of medicinal chemists and, due to their four azol(in)e and four amide donor groups, coordination chemists have become interested in these molecules. The structures of the metal-free macrocycles and their dinuclear copper(II) complexes are known, and solution equilibria, spectroscopic properties and a range of biologically relevant reactions have been studied in detail. However, until recently, the properties of the patellamides and structures of the copper(II) complexes in living systems have not been known unambiguously. These are reviewed in the present Perspective and, as a result, it now is possible to discuss possible biological functions of these species.
（某特定海鞘（热带地区发现的海鞘）的专性共生体）大量产生各种环状假八肽。这些次生代谢产物引起了药物化学家的关注，并且由于其四个唑（啉）和四个酰胺供体基团，配位化学家也对这些分子产生了兴趣。无金属大环及其双核铜（II）配合物的结构是已知的，并且已经详细研究了溶液平衡、光谱性质以及一系列与生物学相关的反应。然而，直到最近，在生物系统中帕特拉酰胺的性质和铜（II）配合物的结构还没有明确的定论。本文对此进行了综述，因此现在可以讨论这些物质可能的生物学功能。
