Fulling K H, Garcia D M
Cancer. 1985 Mar 1;55(5):928-31. doi: 10.1002/1097-0142(19850301)55:5<928::aid-cncr2820550503>3.0.co;2-3.
Initial biopsy and resection specimens from 78 cerebral astrocytomas with anaplastic foci occurring in adults were examined for the presence of five specific histologic features traditionally considered indicative of anaplasia. Anaplastic astrocytomas with foci of tumor necrosis had been classified as glioblastoma multiforme and excluded from this analysis. Median actuarial survival was shorter for patients whose tumors contained vascular endothelial proliferation (3.5 years versus 5.5 years) or greater than 1 mitosis per 10 high power microscopic fields (1 year versus 5.5 years). No correlation with survival was found for estimation of nuclear pleomorphism and cell density or the presence of secondary structures. Vascular endothelial proliferation and increased mitotic activity may serve as prognostically significant histologic markers in cerebral astrocytomas of intermediate malignancy.
对78例发生于成人、具有间变灶的脑星形细胞瘤的初始活检和切除标本进行检查，以确定是否存在传统上被认为是间变指征的五种特定组织学特征。伴有肿瘤坏死灶的间变性星形细胞瘤已被归类为多形性胶质母细胞瘤，被排除在本分析之外。肿瘤含有血管内皮细胞增生的患者的中位精算生存期较短（3.5年对5.5年），或每10个高倍显微镜视野有超过1个有丝分裂的患者的中位精算生存期较短（1年对5.5年）。在核多形性评估、细胞密度或二级结构的存在方面未发现与生存期相关。血管内皮细胞增生和有丝分裂活性增加可能是中度恶性脑星形细胞瘤中具有预后意义的组织学标志物。
