Yang Mingyu, Keller Dávid, Dobolyi Arpád, Valtcheva Silvana
Institute for Systems Physiology, Faculty of Medicine, University of Cologne and University Clinic Cologne, Cologne 50931, Germany.
Institute for Systems Physiology, Faculty of Medicine, University of Cologne and University Clinic Cologne, Cologne 50931, Germany; Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest 1094, Hungary.
Trends Neurosci. 2025 Jan;48(1):33-46. doi: 10.1016/j.tins.2024.11.005. Epub 2024 Dec 12.
The lateral thalamus (LT) receives input from primary sensory nuclei and responds to multimodal stimuli. The LT is also involved in regulating innate and social behaviors through its projections to cortical and limbic networks. However, the importance of multisensory processing within the LT in modulating behavioral output has not been explicitly addressed. Here, we discuss recent findings primarily from rodent studies that extend the classical view of the LT as a passive relay, by underscoring its involvement in associating multimodal features and encoding the salience, valence, and social relevance of sensory signals. We propose that the primary function of the LT is to integrate sensory and non-sensory aspects of multisensory input to gate naturalistic behaviors.
外侧丘脑（LT）接收来自初级感觉核的输入，并对多模态刺激作出反应。LT还通过其向皮质和边缘网络的投射参与调节先天行为和社会行为。然而，LT内多感觉处理在调节行为输出中的重要性尚未得到明确阐述。在此，我们主要讨论来自啮齿动物研究的最新发现，这些发现扩展了将LT视为被动中继的经典观点，强调了其在关联多模态特征以及编码感觉信号的显著性、效价和社会相关性方面的作用。我们提出，LT的主要功能是整合多感觉输入的感觉和非感觉方面，以控制自然行为。
