Sun Zhihong, Tang Hao, Wang Lingyun, Cao Derong
State Key Laboratory of Luminescent Materials and Devices, Department of Chemistry, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, China.
Chemistry. 2025 Feb 12;31(9):e202404217. doi: 10.1002/chem.202404217. Epub 2025 Jan 8.
Chiral macrocycles have recently emerged as promising materials for enantioselective recognition, asymmetric catalysis, and circularly polarized luminescence (CPL) due to their terminal-free structure, preorganized chiral cavities, and unique host-guest and self-assembly properties. This review summarizes recent advances in the design and synthesis of chiral macrocycles with central, axial, helical, and planar chirality, each imparting distinct structural and chiroptical characteristics. We highlight key strategies for constructing these macrocycles and their applications in optoelectronic and catalytic systems. Emphasis is placed on the balance between rigidity and flexibility in macrocycle design, essential for effective molecular recognition, adaptable catalysis, and CPL. We conclude with perspectives on future opportunities, anticipating ongoing developments in chiral macrocycle research.
由于其无末端结构、预组织的手性空腔以及独特的主客体和自组装性质，手性大环最近已成为对映选择性识别、不对称催化和圆偏振发光（CPL）领域有前景的材料。本综述总结了具有中心手性、轴手性、螺旋手性和平面前手性的手性大环在设计和合成方面的最新进展，每种手性都赋予了独特的结构和手性光学特性。我们重点介绍了构建这些大环的关键策略及其在光电和催化系统中的应用。重点在于大环设计中刚性和灵活性之间的平衡，这对于有效的分子识别、适应性催化和CPL至关重要。我们以对未来机遇的展望作为结尾，期待手性大环研究的持续发展。
