Ouyang Min, Wu Jianhua, Hu Xizhuo, Liu Changfu, Zhou Dan
College of Pharmacy, Pingxiang Health Vocational College, Pingxiang, Jiangxi, 337000, PR China.
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China.
J Pharm Pharmacol. 2025 May 2;77(5):593-608. doi: 10.1093/jpp/rgae144.
This review endeavors to elucidate the complex interplay underlying diseases associated with ferroptosis and to delineate the multifaceted mechanisms by which triterpenoid and steroidal saponins modulate this form of cell death.
A meticulous examination of the literature was undertaken, drawing from an array of databases including Web of Science, PubMed, and Wiley Library, with a focus on the keywords "ferroptosis," "saponin," "cancer," "inflammation," "natural products," and "signaling pathways."
Ferroptosis represents a distinctive mode of cell death that holds considerable promise for the development of innovative therapeutic strategies targeting a wide range of diseases, especially cancer and inflammatory disorders. This review reveals the nuanced interactions between saponins and critical signaling pathways, including system Xc--GSH-GPX4, Nrf2, p53, and mTOR. These interactions highlight the dual capacity of saponins to modulate ferroptosis, thereby offering fresh perspectives for therapeutic intervention.
The insights garnered from this review significantly advance our comprehension of the dynamic relationship between saponins and ferroptosis. By shedding light on these mechanisms, this work sets the stage for leveraging these insights in the creation of pioneering approaches to disease treatment, marking a significant stride in the evolution of therapeutic modalities.
本综述旨在阐明与铁死亡相关疾病背后的复杂相互作用，并描述三萜类和甾体皂苷调节这种细胞死亡形式的多方面机制。
对包括科学网、PubMed和Wiley图书馆在内的一系列数据库中的文献进行了细致审查，重点关注关键词“铁死亡”、“皂苷”、“癌症”、“炎症”、“天然产物”和“信号通路”。
铁死亡是一种独特的细胞死亡模式，对于开发针对多种疾病，尤其是癌症和炎症性疾病的创新治疗策略具有很大潜力。本综述揭示了皂苷与关键信号通路（包括系统Xc⁻-谷胱甘肽-谷胱甘肽过氧化物酶4、核因子E2相关因子2、p53和雷帕霉素靶蛋白）之间的细微相互作用。这些相互作用突出了皂苷调节铁死亡的双重能力，从而为治疗干预提供了新的视角。
本综述所获得的见解显著推进了我们对皂苷与铁死亡之间动态关系的理解。通过揭示这些机制，这项工作为利用这些见解创造开创性的疾病治疗方法奠定了基础，标志着治疗方式发展中的重要一步。
