筛选具有高诱导免疫球蛋白A产生、树突状细胞活化和白细胞介素-12产生能力的新型乳酸菌。
Screening of novel lactic acid bacteria with high induction of immunoglobulin A production, dendritic cell activation, and interleukin-12 production.
作者信息
Tsuruno Keigo, Mawatari Takashi, Tanaka-Azuma Yukimasa, Yamatsu Atsushi, Tanabe Soichi
机构信息
Applied Research Laboratory, Ezaki Glico Co., Ltd, Osaka, Japan.
R&D Laboratory, Ezaki Glico Co., Ltd, Osaka, Japan.
出版信息
Biosci Biotechnol Biochem. 2025 Feb 20;89(3):459-464. doi: 10.1093/bbb/zbae196.
In this study, we screened 308 lactic acid bacteria strains for high immunoglobulin A (IgA) production, dendritic cell activation, and interleukin-12 (IL-12) production using human-derived cells. Among them, Lactobacillus helveticus GCL1815 demonstrated superior performance in all aspects, indicating its remarkable potential for immunomodulatory functions in both innate and adaptive immunity.
在本研究中，我们使用人源细胞筛选了308株乳酸菌，以检测其产生高免疫球蛋白A（IgA）、激活树突状细胞和产生白细胞介素-12（IL-12）的能力。其中，瑞士乳杆菌GCL1815在各方面均表现出卓越性能，表明其在固有免疫和适应性免疫中具有显著的免疫调节功能潜力。
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