Naude Colette, Skvarc David, Biurra Yao Coitinho, Blake Lily, Evans Subhadra, Knowles Simon, Eric O, Prasertsung Chatpakorn, Russell Lahiru, Bassili Anna, Mikocka-Walus Antonina
School of Psychology, Deakin University, Burwood/Geelong, Victoria, Australia.
School of Psychology, Deakin University, Burwood/Geelong, Victoria, Australia.
J Psychosom Res. 2025 Feb;189:111984. doi: 10.1016/j.jpsychores.2024.111984. Epub 2024 Nov 16.
The bidirectional relationship between disease activity and mental health in inflammatory bowel disease (IBD) has prompted investigations into the efficacy of psychotherapies, such as mindfulness-based interventions (MBI), for improving biopsychosocial outcomes. Therefore, the aim is to examine the feasibility, acceptability, and preliminary efficacy of an online-delivered, self-directed MBI, adapted to individuals with IBD and psychological distress, in comparison to wait-list control (WLC).
50 adults with IBD were randomized to WLC (N = 25) or intervention (N = 25) groups. The intervention (MIND4IBD program) consisted of six, weekly, 15-min videos (with guided meditations). Feasibility was examined through recruitment and retention rates, while acceptability was examined through intervention satisfaction ratings and qualitative feedback. Preliminary efficacy was examined using linear mixed models for group differences in outcomes between baseline and post-intervention.
Primary Outcomes. The retention rate for the WLC group was 92 %, while the retention rate for the intervention group was 48 %. However, 16 % of participants allocated to the intervention group never began the intervention, therefore this resulted in a retention rate of 71 % of participants who began the intervention. Acceptability was high with an average intervention satisfaction rating of 83/100.
When compared with the WLC, the MIND4IBD program improved total mindfulness levels (b = 0.29, 95 %CI [0.11,0.47], p = 0.004) with a large effect size (β = 0.54, b = 0.19, 95 %CI [0.04,0.34], p = 0.014). Themes based on participants' intervention feedback included: 1) beginning of journey with mindfulness, 2) the beneficial impact of mindfulness, 3) why adapting the intervention to IBD is important, 4) views on program delivery, and 5) mixed reactions to AI generated presenters.
MIND4IBD is feasible and acceptable for individuals with IBD and psychological distress. Participants' total mindfulness levels increased significantly in the intervention group compared to WLC. Most participants provided positive intervention feedback. These findings warrant a full-scale RCT to determine MIND4IBD's efficacy for IBD.
炎症性肠病（IBD）中疾病活动与心理健康之间的双向关系促使人们对心理治疗的疗效进行研究，如基于正念的干预措施（MBI），以改善生物心理社会结局。因此，本研究旨在探讨一种针对患有IBD和心理困扰的个体的在线自助式MBI与等待名单对照（WLC）相比的可行性、可接受性和初步疗效。
50名成年IBD患者被随机分为WLC组（N = 25）或干预组（N = 25）。干预措施（MIND4IBD项目）包括六个每周一次、每次15分钟的视频（带有引导冥想）。通过招募和留存率来检验可行性，通过干预满意度评分和定性反馈来检验可接受性。使用线性混合模型检验基线与干预后组间结局差异的初步疗效。
主要结局。WLC组的留存率为92%，而干预组的留存率为48%。然而，分配到干预组的参与者中有16%从未开始干预，因此这导致开始干预的参与者留存率为71%。可接受性较高，干预满意度平均评分为83/100。
与WLC相比，MIND4IBD项目提高了总体正念水平（b = 0.29，95%CI [0.11,0.47]，p = 0.004），效应量较大（β = 0.54，b = 0.19，95%CI [0.04,0.34]，p = 0.014）。基于参与者干预反馈的主题包括：1）正念之旅的开始，2）正念的有益影响，3）为何使干预措施适应IBD很重要，4）对项目实施的看法，以及5）对人工智能生成的讲解者的不同反应。
MIND4IBD对于患有IBD和心理困扰的个体是可行且可接受的。与WLC相比，干预组参与者的总体正念水平显著提高。大多数参与者提供了积极的干预反馈。这些发现值得进行一项全面的随机对照试验来确定MIND4IBD对IBD的疗效。
