Zhang Jin-Zhi, Liu Chang-Hai, Shen Ya-Lin, Song Xiao-Na, Tang Hong, Li Hong
Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China; Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.
Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China; Laboratory of Infectious and Liver Diseases, Institute of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.
Ageing Res Rev. 2025 Feb;104:102628. doi: 10.1016/j.arr.2024.102628. Epub 2024 Dec 13.
Sarcopenia is associated with poor prognosis and mortality following injury. This systematic review and meta-analysis aimed to analyze diagnostic criteria for sarcopenia, as well as to assess its prevalence and impact on health outcomes among trauma patients. We conducted a literature search on MEDLINE, EMBASE, and the Cochrane Library from inception to June 2023. A total of 27 studies were included, involving 8692 individuals (55.5 % men) with a mean age ranging from 42.2 to 80.5 years. The pooled prevalence of sarcopenia in trauma patients was 36.0 % [95 % confidence interval (CI): 29.1-43.0 %, I = 97.8 %], with a 39.3 % prevalence (95 % CI: 31.0-48.5 %, I = 96.8 %) in men and a 39.0 % prevalence (95 % CI: 31.4-46.2 %, I = 94.4 %) in women. Trauma patients with sarcopenia were more prone to complications [risk ratio (RR): 1.16, 95 % CI: 1.03-1.31, I = 45.8 %] and less able to discharge independently (RR: 0.74, 95 % CI: 0.63-0.86, I = 33.3 %). The risk of death in trauma patients with sarcopenia was higher than in non-sarcopenic patients [hazard ratio (HR): 1.64, 95 % CI: 1.31-2.04]. Sarcopenia is commonly present in trauma patients and has a negative impact on prognosis. Early assessment and interventions for sarcopenia should be conducted in trauma patients.
肌肉减少症与受伤后的不良预后和死亡率相关。本系统评价和荟萃分析旨在分析肌肉减少症的诊断标准，并评估其在创伤患者中的患病率及其对健康结局的影响。我们对MEDLINE、EMBASE和Cochrane图书馆进行了从创刊至2023年6月的文献检索。共纳入27项研究，涉及8692名个体（55.5%为男性），平均年龄在42.2至80.5岁之间。创伤患者中肌肉减少症的合并患病率为36.0%[95%置信区间（CI）：29.1 - 43.0%，I = 97.8%]，男性患病率为39.3%（95%CI：31.0 - 48.5%，I = 96.8%），女性患病率为39.0%（95%CI：31.4 - 46.2%，I = 94.4%）。患有肌肉减少症的创伤患者更容易出现并发症[风险比（RR）：1.16，95%CI：1.03 - 1.31，I = 45.8%]，且独立出院能力较低（RR：0.74，95%CI：0.63 - 0.86，I = 33.3%）。患有肌肉减少症的创伤患者的死亡风险高于非肌肉减少症患者[风险比（HR）：1.64，95%CI：1.31 - 2.04]。肌肉减少症在创伤患者中普遍存在，且对预后有负面影响。应对创伤患者进行肌肉减少症的早期评估和干预。
