Qi Chenchen, Liu Xudong, Mao Jing, Zhang Sen, Ye Lan, Wang Xuan, Peng Jianan, Zhou Xiaoling
Department of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, China; Department of Nephrology, NO215.Hospital of Shaanxi Nuclear Industry, Xianyang, China.
Department of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, China.
Nutr Metab Cardiovasc Dis. 2025 Mar;35(3):103800. doi: 10.1016/j.numecd.2024.103800. Epub 2024 Nov 20.
To understand the clinical and pathological characteristics of patients with IgA nephropathy (IgAN) complicated by hyperuricemia, and to analyze the time-averaged SUA (TA-SUA) on the prognosis of IgAN.
A retrospective analysis of 718 IgAN patients with diagnosis confirmed by renal biopsy and follow-up of more than 1 year was performed. At least two serum uric acid (SUA) levels were measured at intervals of 0.5-1 year during follow-up. The TA-SUA was calculated according to the area under the curve during the follow-up period. The primary endpoint of the study was the doubling of creatinine or end-stage renal disease. Four groups (Q1-Q4) were divided according to TA-SUA quartile spacing from low to high, and the association of the TA-SUA with prognosis in IgAN patients was assessed using Kaplan-Meier survival analysis and Cox proportional hazards models. This study included 718 patients with IgAN, of whom 181 (25.21 %) had hyperuricemia.Compared with the other three groups, the clinical and pathological characteristics of patients in the fourth quarter were more severe in both baseline SUA and TA-SUA groups. Multivariate results suggested that baseline SUA was not an independent risk factor for renal prognosis in IgAN patients after adjustment for clinical variables such as eGFR. High TA-SUA is an independent risk factor for renal prognosis in IgAN patients.
Hyperuricemia is common in IgA nephropathy.High TA-SUA in IgAN patients show more severe clinical features and pathological damage. TA-SUA is an independent risk factor for renal prognosis in IgA nephropathy patients.
了解IgA肾病（IgAN）合并高尿酸血症患者的临床及病理特征，并分析IgAN患者的时间平均血尿酸（TA-SUA）对预后的影响。
对718例经肾活检确诊且随访时间超过1年的IgAN患者进行回顾性分析。随访期间每隔0.5 - 1年至少测量两次血清尿酸（SUA）水平。根据随访期间曲线下面积计算TA-SUA。研究的主要终点是肌酐翻倍或终末期肾病。根据TA-SUA四分位数间距由低到高将患者分为四组（Q1 - Q4），采用Kaplan-Meier生存分析和Cox比例风险模型评估TA-SUA与IgAN患者预后的相关性。本研究纳入718例IgAN患者，其中181例（25.21%）有高尿酸血症。与其他三组相比，第四组患者在基线SUA和TA-SUA组中的临床和病理特征更为严重。多因素结果显示，在调整eGFR等临床变量后，基线SUA不是IgAN患者肾脏预后的独立危险因素。高TA-SUA是IgAN患者肾脏预后的独立危险因素。
高尿酸血症在IgA肾病中常见。IgAN患者中高TA-SUA表现出更严重的临床特征和病理损害。TA-SUA是IgA肾病患者肾脏预后的独立危险因素。
