Hoeprich P D, Huston A C, Wolfe B M
Diagn Microbiol Infect Dis. 1985 Jan;3(1):47-58. doi: 10.1016/0732-8893(85)90066-5.
Conditioned mongrel dogs were given 30 i.v. injections of either AMB (amphotericin B, 0.75 mg/kg body weight), AME (amphotericin B methyl ester, 10 mg/kg body weight), or 5% glucose solution without antimicrobic. Severe loss of body weight and nephrotoxicity occurred with AMB; hepatic dysfunction resulted with AME; astrogliosis and pallor of the myelin were found in dogs given AME and 5% glucose solution.
给条件反射的杂种狗静脉注射30次，分别注射两性霉素B（AMB，0.75毫克/千克体重）、两性霉素B甲酯（AME，10毫克/千克体重）或不含抗菌剂的5%葡萄糖溶液。接受AMB注射的狗出现了严重体重减轻和肾毒性；接受AME注射的狗出现了肝功能障碍；接受AME和5%葡萄糖溶液注射的狗出现了星形胶质细胞增生和髓鞘苍白。
