人类胎儿固有淋巴细胞独特的组织依赖性组成和基因表达
Distinct Tissue-Dependent Composition and Gene Expression of Human Fetal Innate Lymphoid Cells.
作者信息
Rødahl Inga E, Ivarsson Martin A, Loh Liyen, Mold Jeff E, Westgren Magnus, Friberg Danielle, Mjösberg Jenny, Björkström Niklas K, Marquardt Nicole, Nixon Douglas F, Michaëlsson Jakob
机构信息
Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Division of Experimental Medicine, Department of Medicine, University of California San Francisco, San Francisco, USA.
出版信息
Eur J Immunol. 2025 Feb;55(2):e202451150. doi: 10.1002/eji.202451150. Epub 2024 Dec 15.
The human fetal immune system starts to develop in the first trimester and likely plays a crucial role in fetal development and maternal-fetal tolerance. Innate lymphoid cells (ILCs) are the earliest lymphoid cells to arise in the human fetus. ILCs consist of natural killer (NK) cells, ILC1s, ILC2s, and ILC3s that all share a common lymphoid origin. Here, we studied fetal ILC subsets, mainly NK cells and ILC3s and their potential progenitors, across human fetal tissues. Our results show that fetal ILC subsets have distinct distribution, developmental kinetics, and gene expression profiles across human fetal tissues. Furthermore, we identify CD34RORγtEomes and CD34RORγtEomes cells in the fetal intestine, indicating that tissue-specific ILC progenitors exist already during fetal development.
人类胎儿免疫系统在妊娠早期开始发育，可能在胎儿发育和母胎耐受中发挥关键作用。固有淋巴细胞（ILC）是人类胎儿中最早出现的淋巴细胞。ILC由自然杀伤（NK）细胞、ILC1、ILC2和ILC3组成，它们都有共同的淋巴起源。在此，我们研究了人类胎儿组织中的胎儿ILC亚群，主要是NK细胞和ILC3及其潜在祖细胞。我们的结果表明，胎儿ILC亚群在人类胎儿组织中具有不同的分布、发育动力学和基因表达谱。此外，我们在胎儿肠道中鉴定出CD34RORγtEomes和CD34RORγtEomes细胞，表明在胎儿发育期间就已经存在组织特异性ILC祖细胞。
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