Chen Xiaohui, Yao Huajie, Lai Jiaqi, Chen Yanmei, Li Xiaodong, Li Shanshan, Li Ling, He Fazhong
Department of Quality Control, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, China.
College of Pharmacy, Jinan University, Guangzhou, China.
Curr Diabetes Rev. 2025;21(4):94-105. doi: 10.2174/0115733998288601240327065724.
Cardiovascular complications are a primary focus in the clinical management of type 2 diabetes, as they are the leading causes of disability and mortality in individuals with diabetes. Insulin resistance and endothelial dysfunction commonly coexist in diabetic patients. An increasing body of research indicates a reciprocal and interconnected association between endothelial function and insulin resistance. Insulin resistance can manifest in two distinct forms: endothelial and metabolic, with the former predominantly affecting vascular endothelial cells and the latter primarily impacting peripheral cells. The understanding of endothelial insulin resistance is crucial in comprehending the pathophysiology of cardiovascular complications in type 2 diabetes. Hence, the objective of this study is to examine the correlations, interplays, and molecular pathways linking endothelial insulin resistance and metabolic insulin resistance, with the aim of offering novel insights and scholarly resources for the prevention and management of diabetic vascular complications.
心血管并发症是2型糖尿病临床管理的主要关注点，因为它们是糖尿病患者致残和死亡的主要原因。胰岛素抵抗和内皮功能障碍在糖尿病患者中通常并存。越来越多的研究表明内皮功能与胰岛素抵抗之间存在相互关联。胰岛素抵抗可表现为两种不同形式：内皮型和代谢型，前者主要影响血管内皮细胞，后者主要影响外周细胞。理解内皮胰岛素抵抗对于理解2型糖尿病心血管并发症的病理生理学至关重要。因此，本研究的目的是探讨内皮胰岛素抵抗与代谢性胰岛素抵抗之间的相关性、相互作用及分子途径，旨在为糖尿病血管并发症的预防和管理提供新的见解和学术资源。
