Instrumentation of the cervical spine particularly at the higher cervical levels like C2 presents unique challenges mainly because of their complex anatomy and proximity to neurovascular structures. The goal of the article is to demonstrate that using navigation technologies in inserting anterior odontoid screws can enhance the precision and safety of surgery. We describe a novel approach for anterior C2 odontoid fixation using a three-pin radiolucent Mayfield clamp with intra-operative CT registration and cranial brainlab navigation. A 28-year-old male patient who had a type II odontoid fracture was treated by this innovative technique using a radiolucent Mayfield clamp and cranial Brainlab navigation system to increase the precision of screw placement in the cervical spine and reduce the usage of X-ray during the procedure. The application of this technique results in the appropriate placement of the odontoid screw with limited neck exposure and less operative time. This novel surgical technique represents a significant advancement in the surgical treatment of patients with type II odontoid fractures by offering enhanced precision and safety and reduced surgical trauma. Its successful application in this challenging cervical spine surgery proves its potential in the anterior approach of cervical spine surgery.