• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗环瓜氨酸肽阳性的风湿免疫相关不良事件与皮肤药物不良反应：一例报告

Rheumatic Immune-Related Adverse Events With Anti-cyclic Citrullinated Peptide Positivity and Cutaneous Adverse Drug Reactions: A Case Report.

作者信息

Yamazaki Akiko, Nakano Eiji, Yoshida Tomohiko

机构信息

Rheumatology, Setagaya Rheumatology Clinic, Tokyo, JPN.

Department of Dermatologic Oncology, National Cancer Center Hospital, Tokyo, JPN.

出版信息

Cureus. 2024 Nov 15;16(11):e73774. doi: 10.7759/cureus.73774. eCollection 2024 Nov.

DOI:10.7759/cureus.73774
PMID:39677189
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11646650/
Abstract

We report the case of a patient who experienced rheumatic immune-related adverse events (irAEs) with anti-cyclic citrullinated peptide (anti-CCP) positivity and cutaneous adverse drug reactions. A 59-year-old woman with malignant melanoma who was treated with nivolumab as postoperative adjuvant therapy developed polyarthralgia with anti-CCP positivity and dermatologic adverse events caused by celecoxib or lansoprazole. Her rheumatic and cutaneous symptoms greatly improved with oral glucocorticoid treatment. The findings of this case suggest that after treatment with immune checkpoint inhibitors, it is necessary to pay attention to irAEs and provide appropriate treatment.

摘要

我们报告了一例出现风湿免疫相关不良事件（irAEs）且抗环瓜氨酸肽（anti-CCP）呈阳性以及皮肤药物不良反应的患者。一名59岁患有恶性黑色素瘤的女性，接受纳武单抗作为术后辅助治疗，出现了抗CCP阳性的多关节痛以及由塞来昔布或兰索拉唑引起的皮肤不良事件。口服糖皮质激素治疗后，她的风湿和皮肤症状有了显著改善。该病例的结果表明，在使用免疫检查点抑制剂治疗后，有必要关注irAEs并提供适当治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62dc/11646650/84acbcdfdb9a/cureus-0016-00000073774-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62dc/11646650/35f678e6dc83/cureus-0016-00000073774-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62dc/11646650/c08e7ad7a30c/cureus-0016-00000073774-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62dc/11646650/d131015a00d1/cureus-0016-00000073774-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62dc/11646650/84acbcdfdb9a/cureus-0016-00000073774-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62dc/11646650/35f678e6dc83/cureus-0016-00000073774-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62dc/11646650/c08e7ad7a30c/cureus-0016-00000073774-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62dc/11646650/d131015a00d1/cureus-0016-00000073774-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62dc/11646650/84acbcdfdb9a/cureus-0016-00000073774-i04.jpg

相似文献

1
Rheumatic Immune-Related Adverse Events With Anti-cyclic Citrullinated Peptide Positivity and Cutaneous Adverse Drug Reactions: A Case Report.抗环瓜氨酸肽阳性的风湿免疫相关不良事件与皮肤药物不良反应：一例报告
Cureus. 2024 Nov 15;16(11):e73774. doi: 10.7759/cureus.73774. eCollection 2024 Nov.
2
Rheumatoid Arthritis Symptoms Diagnosed by Rheumatic Immune-related Adverse Events Caused by Nivolumab in a Patient with Esophageal Cancer.纳武利尤单抗致食管癌患者风湿免疫相关不良事件引发类风湿关节炎的诊断
Intern Med. 2023 Jan 15;62(2):215-220. doi: 10.2169/internalmedicine.9663-22. Epub 2022 Jun 21.
3
Association Between Rheumatic Autoantibodies and Immune-Related Adverse Events.风湿自身抗体与免疫相关不良事件的关联。
Oncologist. 2023 May 8;28(5):440-448. doi: 10.1093/oncolo/oyac252.
4
Neurologic Serious Adverse Events Associated with Nivolumab Plus Ipilimumab or Nivolumab Alone in Advanced Melanoma, Including a Case Series of Encephalitis.纳武单抗联合伊匹单抗或单独使用纳武单抗治疗晚期黑色素瘤相关的神经系统严重不良事件，包括一组脑炎病例
Oncologist. 2017 Jun;22(6):709-718. doi: 10.1634/theoncologist.2016-0487. Epub 2017 May 11.
5
Immune checkpoint inhibitor (nivolumab)-associated kidney injury and the importance of recognizing concomitant medications known to cause acute tubulointerstitial nephritis: a case report.免疫检查点抑制剂（纳武利尤单抗）相关肾损伤以及识别已知可引起急性肾小管间质性肾炎的伴随用药的重要性：一例报告
BMC Nephrol. 2018 Feb 27;19(1):48. doi: 10.1186/s12882-018-0848-y.
6
Autoantibody-positivity before and seroconversion during treatment with anti-PD-1 is associated with immune-related adverse events in patients with melanoma.抗 PD-1 治疗前和治疗期间的自身抗体阳性与黑色素瘤患者的免疫相关不良事件相关。
J Immunother Cancer. 2024 Jun 30;12(6):e009215. doi: 10.1136/jitc-2024-009215.
7
Adverse cutaneous toxicities by PD-1/PD-L1 immune checkpoint inhibitors: pathogenesis, treatment, and surveillance.PD-1/PD-L1 免疫检查点抑制剂的皮肤毒性不良反应：发病机制、治疗和监测。
Cutan Ocul Toxicol. 2022 Mar;41(1):73-90. doi: 10.1080/15569527.2022.2034842. Epub 2022 Feb 20.
8
A rare case of eosinophilic gastritis induced by nivolumab therapy for metastatic melanoma.纳武利尤单抗治疗转移性黑色素瘤致嗜酸性粒细胞性胃炎 1 例罕见报告
Clin J Gastroenterol. 2022 Oct;15(5):876-880. doi: 10.1007/s12328-022-01680-y. Epub 2022 Aug 17.
9
Rheumatoid arthritis and polymyalgia rheumatica occurring after immune checkpoint inhibitor treatment.免疫检查点抑制剂治疗后出现的类风湿关节炎和巨细胞动脉炎。
Ann Rheum Dis. 2017 Oct;76(10):1747-1750. doi: 10.1136/annrheumdis-2017-211216. Epub 2017 Jun 9.
10
Real world comparison of immune-related adverse events with nivolumab-relatlimab versus ipilimumab-nivolumab in patients with advanced cutaneous melanoma.纳武单抗-瑞派利单抗与伊匹木单抗-纳武单抗治疗晚期皮肤黑色素瘤患者时免疫相关不良事件的真实世界比较
J Oncol Pharm Pract. 2024 Dec 5:10781552241303698. doi: 10.1177/10781552241303698.

本文引用的文献

1
Association Between Rheumatic Autoantibodies and Immune-Related Adverse Events.风湿自身抗体与免疫相关不良事件的关联。
Oncologist. 2023 May 8;28(5):440-448. doi: 10.1093/oncolo/oyac252.
2
Immune checkpoint inhibitor-related dermatologic adverse events.免疫检查点抑制剂相关的皮肤不良反应。
J Am Acad Dermatol. 2020 Nov;83(5):1255-1268. doi: 10.1016/j.jaad.2020.03.132. Epub 2020 May 23.
3
EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors.
EULAR 针对癌症免疫治疗中使用检查点抑制剂引起的风湿免疫相关不良事件的诊断和管理的考虑要点。
Ann Rheum Dis. 2021 Jan;80(1):36-48. doi: 10.1136/annrheumdis-2020-217139. Epub 2020 Apr 23.
4
Inflammatory tenosynovitis and enthesitis induced by immune checkpoint inhibitor treatment.免疫检查点抑制剂治疗引起的炎症性腱鞘炎和肌腱端炎。
Clin Rheumatol. 2018 Apr;37(4):1107-1110. doi: 10.1007/s10067-018-4035-0. Epub 2018 Feb 17.
5
Rheumatic manifestations among cancer patients treated with immune checkpoint inhibitors.免疫检查点抑制剂治疗的癌症患者中的风湿表现。
Autoimmun Rev. 2018 Mar;17(3):284-289. doi: 10.1016/j.autrev.2018.01.003. Epub 2018 Jan 16.
6
Rheumatic disorders associated with immune checkpoint inhibitors in patients with cancer-clinical aspects and relationship with tumour response: a single-centre prospective cohort study.癌症患者免疫检查点抑制剂相关风湿性疾病的临床特征及其与肿瘤应答的关系：单中心前瞻性队列研究。
Ann Rheum Dis. 2018 Mar;77(3):393-398. doi: 10.1136/annrheumdis-2017-212257. Epub 2017 Nov 16.
7
Cytotoxic Cutaneous Adverse Drug Reactions during Anti-PD-1 Therapy.抗 PD-1 治疗中的细胞毒性皮肤不良反应。
Clin Cancer Res. 2016 Aug 15;22(16):4023-9. doi: 10.1158/1078-0432.CCR-15-2872. Epub 2016 Mar 8.
8
In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates.抗 PD-1 抗体nivolumab（BMS-936558）的体外特征分析和在非人灵长类动物中的体内毒理学研究。
Cancer Immunol Res. 2014 Sep;2(9):846-56. doi: 10.1158/2326-6066.CIR-14-0040. Epub 2014 May 28.