急性和慢性吗啡对脑心输出量区域分布的影响。

The effects of acute and chronic morphine on regional distribution of cardiac output in brain.

作者信息

Law W R, Ritzmann R F, Lee J M, Kapin M A, Ferguson J L

出版信息

Experientia. 1985 Jan 15;41(1):78-80. doi: 10.1007/BF02005885.

DOI:10.1007/BF02005885

Abstract

Both acute and chronic administration of morphine resulted in an increase in the percent cardiac output received by brain. However, various brain regions were affected differently by the drug treatments. The greatest increases in percent cardiac output received after chronic administration of morphine occurred in pons and cerebellum, while the greatest increases after acute administration occurred in cortex and midbrain. The changes found are in contrast with earlier studies which suggest that morphine has no effect on cerebral blood flow.

摘要

吗啡的急性和慢性给药均导致大脑所接受的心输出量百分比增加。然而，不同脑区受药物治疗的影响有所不同。慢性给予吗啡后，脑桥和小脑中的心输出量百分比增加最为显著，而急性给药后，大脑皮层和中脑的心输出量百分比增加最为显著。这些发现与早期研究结果相反，早期研究表明吗啡对脑血流量没有影响。