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通过用(14C)脱氧葡萄糖对局部代谢率进行放射自显影测量来绘制功能性神经通路图。

Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with (14C)deoxyglucose.

作者信息

Kennedy C, Des Rosiers M H, Jehle J W, Reivich M, Sharpe F, Sokoloff L

出版信息

Science. 1975 Mar 7;187(4179):850-3. doi: 10.1126/science.1114332.

DOI:10.1126/science.1114332
PMID:1114332
Abstract

An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido(3,4-b)indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human tissues has been described.

摘要

人脑的一种酶制剂在5-甲基四氢叶酸存在的情况下可将色胺转化为色醇(9H-1,2,3,4-四氢吡啶并(3,4-b)吲哚)。同样,N-甲基色胺和5-羟色胺分别生成1-甲基色醇和5-羟色醇。人体组织在体外或体内均未被描述会形成这些化合物。

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Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with (14C)deoxyglucose.通过用(14C)脱氧葡萄糖对局部代谢率进行放射自显影测量来绘制功能性神经通路图。
Science. 1975 Mar 7;187(4179):850-3. doi: 10.1126/science.1114332.
2
Tryptoline formation by a preparation from brain with 5-methyltetrahydrofolic acid and tryptamine.用来自大脑的制剂、5-甲基四氢叶酸和色胺形成色氨酸。
Science. 1975 Mar 7;187(4179):853-5. doi: 10.1126/science.234627.
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Regional cerebral glucose utilization measured with the 2--[ 14C] deoxyglucose technique: its use in mapping functional activity in the nervous system.用2-[¹⁴C]脱氧葡萄糖技术测量局部脑葡萄糖利用:其在绘制神经系统功能活动图中的应用。
Acta Neurol Scand Suppl. 1980;78:128-46. doi: 10.1111/j.1600-0404.1980.tb05432.x.
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Mapping of local cerebral functional activity by measurement of local cerebral glucose utilization with [14C]deoxyglucose.通过用[14C]脱氧葡萄糖测量局部脑葡萄糖利用来绘制局部脑功能活动图。
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Patterns of activity in pigeon brain's visual relays as revealed by the [14C]2-deoxyglucose method.用[14C]2-脱氧葡萄糖法揭示的鸽脑视觉中继中的活动模式。
Neuroscience. 1980;5(6):1053-66. doi: 10.1016/0306-4522(80)90186-4.
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Neural substrates for long-term habituation of the acoustic startle reflex in rats: a 2-deoxyglucose study.大鼠听觉惊跳反射长期习惯化的神经基质:一项2-脱氧葡萄糖研究。
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[Functional study of the rat olfactory bulb by a 14C-2-deoxyglucose autoradiographic technic].
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Hippocampal afterdischarges: differential spread of activity shown by the [14C]deoxyglucose technique.
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Increased uptake of [3H]deoxyglucose and [14C]deoxyglucose in localized regions of the brain during stimulation of the motor cortex.在刺激运动皮层期间,大脑局部区域对[3H]脱氧葡萄糖和[14C]脱氧葡萄糖的摄取增加。
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Brain Res. 1979 Jul 13;170(2):353-8. doi: 10.1016/0006-8993(79)90113-6.

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