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通过用(14C)脱氧葡萄糖对局部代谢率进行放射自显影测量来绘制功能性神经通路图。

Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with (14C)deoxyglucose.

作者信息

Kennedy C, Des Rosiers M H, Jehle J W, Reivich M, Sharpe F, Sokoloff L

出版信息

Science. 1975 Mar 7;187(4179):850-3. doi: 10.1126/science.1114332.

Abstract

An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1,2,3,4-tetrahydropyrido(3,4-b)indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline, respectively. Neither in vitro nor in vivo formation of these compounds by human tissues has been described.

摘要

人脑的一种酶制剂在5-甲基四氢叶酸存在的情况下可将色胺转化为色醇(9H-1,2,3,4-四氢吡啶并(3,4-b)吲哚)。同样,N-甲基色胺和5-羟色胺分别生成1-甲基色醇和5-羟色醇。人体组织在体外或体内均未被描述会形成这些化合物。

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