Plotnikoff N P, Murgo A J, Miller G C, Corder C N, Faith R E
Fed Proc. 1985 Jan;44(1 Pt 1):118-22.
Our original studies of the enkephalins were centered on behavioral stress and brain dopaminergic interactions. More recently we discovered the enkephalins to be immunomodulators as evidenced by their enhancement effects on lymphocyte blastogenesis in mice, increases in the sizes of the thymus or spleen in rodents, and prolongation of survival of BDF1 mice inoculated with attentuated L1210 cells. Finally, in studies of human blood samples from both normal volunteers and cancer patients, the enkephalins were demonstrated to stimulate active T cell rosettes and natural killer cell activities (in vitro). These studies support our hypothesis that, in stress, the enkephalins modulate the effects of steroid hormones on the immune system.
我们最初对脑啡肽的研究集中在行为应激和脑多巴胺能相互作用上。最近我们发现脑啡肽是免疫调节剂，这在小鼠淋巴细胞增殖、啮齿动物胸腺或脾脏大小增加以及接种减毒L1210细胞的BDF1小鼠存活期延长中得到了证实。最后，在对正常志愿者和癌症患者的人类血液样本的研究中，脑啡肽被证明能刺激活性T细胞玫瑰花结形成和自然杀伤细胞活性（体外）。这些研究支持了我们的假设，即在应激状态下，脑啡肽调节类固醇激素对免疫系统的作用。
