Gao Linli, Zhao Fangling, Tu Yujie, Liu Kaiming
Department of Cardiology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Cardiovascular Key Laboratory of Zhejiang Province, Hangzhou, China.
Front Neurol. 2024 Nov 29;15:1496401. doi: 10.3389/fneur.2024.1496401. eCollection 2024.
Migraine is a common clinical chronic neurovascular disease characterized by recurrent, mostly unilateral, moderate or severe, pulsatile headache. It can be divided into four clinical stages: premonitory (prodrome), aura, headache and postdrome. The early warning value of the prodrome in migraine has been largely verified in various studies. In fact, the prodrome of migraine has received increasing attention as it can serve as an ideal therapeutic window for early intervention and effective treatment of migraine. In recent years, the pathophysiological and molecular biological mechanisms in the prodromal stage of migraine have been extensively studied, and great progress has been made in understanding the disease. This review paper aims to provide an overview of recent studies mainly focused on the prodrome of migraine, discuss the biological mechanisms underlying the clinical profile, and reveal novel therapeutic strategies for preventing or blocking migraine onset during its prodrome.
偏头痛是一种常见的临床慢性神经血管疾病，其特征为反复发作，大多为单侧、中度或重度搏动性头痛。它可分为四个临床阶段：先兆期（前驱症状）、先兆、头痛期和头痛后期。偏头痛前驱症状的预警价值在各项研究中已得到很大程度的证实。事实上，偏头痛的前驱症状越来越受到关注，因为它可作为偏头痛早期干预和有效治疗的理想治疗窗口。近年来，偏头痛前驱期的病理生理和分子生物学机制得到了广泛研究，在对该疾病的认识上取得了很大进展。这篇综述旨在概述近期主要聚焦于偏头痛前驱症状的研究，讨论临床特征背后的生物学机制，并揭示在偏头痛前驱期预防或阻止其发作的新治疗策略。
