van Dantzig Philippa, Lao Chunhuan, Padala Sree Deepika, White Douglas, Solanki Kamal
Rheumatology Department, Waikato Hospital, Hamilton, New Zealand.
Medical Research Centre, The University of Waikato, Hamilton, New Zealand.
J Scleroderma Relat Disord. 2024 Dec 11:23971983241299294. doi: 10.1177/23971983241299294.
Systemic sclerosis is associated with significant morbidity and mortality. It remains unclear from the literature if there are differences between the subtypes of systemic sclerosis and the rate of hospitalization. Our study investigates the rates of all types of hospitalizations between limited and diffuse cutaneous systemic sclerosis.
Patients have been collected prospectively using the European Scleroderma Trials and Research Group database at the Waikato Hospital, and were screened for inclusion criteria. Data were collected retrospectively on hospitalizations (total, acute, elective and infusion-related) for all patients.
Overall, 140 patients were included in the analysis with 84 (60.0%) with limited cutaneous systemic sclerosis, 40 (28.6%) with diffuse systemic sclerosis, 3 (2.1%) with systemic sclerosis sine scleroderma and 13 (9.3%) with overlap syndrome. The mean number of total hospitalizations in 12 months was 0.9 (SD 3.0) for patients with limited disease versus 1.7 (SD 3.0) for diffuse disease (p = 0.062). The mean number of acute hospitalizations in 12 months was 0.6 (SD 1.3) for limited and 1.2 (SD 2.4) for diffuse (p = 0.061). Patients with diffuse systemic sclerosis were more likely to be admitted for reasons relating to systemic sclerosis than patients with limited disease (p < 0.001).
Diffuse and limited systemic sclerosis subtypes appear to have similar rates of hospitalizations though there is a trend in favour of diffuse disease towards more total and acute hospitalizations. There are clear differences in causes of hospitalization between the two main subgroups.
系统性硬化症与较高的发病率和死亡率相关。从文献中尚不清楚系统性硬化症的亚型与住院率之间是否存在差异。我们的研究调查了局限性和弥漫性皮肤系统性硬化症患者各类住院情况的发生率。
前瞻性收集怀卡托医院欧洲硬皮病试验与研究组数据库中的患者，并根据纳入标准进行筛选。回顾性收集所有患者的住院数据（包括总住院次数、急性住院次数、择期住院次数和输液相关住院次数）。
总体而言，140例患者纳入分析，其中84例（60.0%）为局限性皮肤系统性硬化症，40例（28.6%）为弥漫性系统性硬化症，3例（2.1%）为无硬皮病的系统性硬化症，13例（9.3%）为重叠综合征。局限性疾病患者12个月内的总住院次数平均为0.9次（标准差3.0），而弥漫性疾病患者为1.7次（标准差3.0）（p = 0.062）。局限性疾病患者12个月内的急性住院次数平均为0.6次（标准差1.3），弥漫性疾病患者为1.2次（标准差2.4）（p = 0.061）。与局限性疾病患者相比，弥漫性系统性硬化症患者因系统性硬化症相关原因入院的可能性更大（p < 0.001）。
弥漫性和局限性系统性硬化症亚型的住院率似乎相似，不过有趋势表明弥漫性疾病的总住院次数和急性住院次数更多。两个主要亚组之间的住院原因存在明显差异。
