Goulding A, McIntosh J
Horm Metab Res. 1985 Jan;17(1):50-1. doi: 10.1055/s-2007-1013450.
This study was undertaken to examine the effects of hydrochlorothiazide treatment on urinary hydroxyproline excretion in parathyroidectomized rats. Urinary hydroxyproline (mumol/24 hr) fell significantly in thiazide-treated rats compared with control animals (5.66 +/- 0.37 versus 7.30 +/- 0.6, P less than 0.05, means +/- SEM). This fall in hydroxyproline excretion occurred without a decrease in glomerular filtration rate. It is concluded that the ability of thiazide diuretics to reduce urinary hydroxyproline excretion is not dependent upon suppression of parathyroid hormone-mediated bone turnover.
本研究旨在探讨氢氯噻嗪治疗对甲状旁腺切除大鼠尿羟脯氨酸排泄的影响。与对照动物相比，噻嗪类药物治疗的大鼠尿羟脯氨酸（微摩尔/24小时）显著下降（5.66±0.37对7.30±0.6，P<0.05，均值±标准误）。羟脯氨酸排泄的这种下降发生在肾小球滤过率无降低的情况下。得出的结论是，噻嗪类利尿剂降低尿羟脯氨酸排泄的能力不依赖于甲状旁腺激素介导的骨转换的抑制。
