Li Zonglin, Lei Xiao, Zhang Zhe
Department of Traditional Chinese Medicine, Affiliated Hospital of North Sichuan Medical College Nanchong 637000, Sichuan, China.
Am J Transl Res. 2024 Nov 15;16(11):6699-6708. doi: 10.62347/KMLD8349. eCollection 2024.
To study the effects of Changtong Paste on gastrointestinal function after colorectal cancer surgery.
A retrospective analysis was conducted on the clinical data of 216 patients who underwent colorectal cancer surgery at the Affiliated Hospital of North Sichuan Medical College from June 2021 to June 2023. Patients were divided into two groups according to their treatment plan: the control group (n=109), who received abdominal multi-source therapy irradiation, and the study group (n=107), who received Changtong Paste in conjunction with the same abdominal irradiation therapy. The two groups were compared in terms of hemorheology, gastrointestinal hormones, immune function, cancer-related fatigue, quality of life, gastrointestinal function, duration of hospital stay, and clinical efficacy.
After treatment, both groups demonstrated significant reductions in plasma viscosity, erythrocyte sedimentation rate, high-shear and low-shear whole blood viscosity, somatostatin (SS), vasoactive intestinal peptide (VIP), and scores on the Piper Fatigue Scale-Revised (PFS-R) compared to before treatment, with the study group showing lower levels. Conversely, levels of motilin (MTL), immunoglobulin G (IgG), IgA, IgM, and Quality of Life Questionnaire (QLQ-C30) scores significantly increased after treatment, with the study group showing higher values (P < 0.05). Additionally, indicators for gastrointestinal function recovery and length of hospital stay were shorter in the study group than in the control group (P < 0.05). The total clinical effective rate in the study group (94.39%) was higher than that of the control group (84.40%) (P < 0.05).
Changtong Paste therapy can effectively regulate hemorheology, improve gastrointestinal hormone levels, promote gastrointestinal and immune function recovery, alleviate cancer-related fatigue, enhance quality of life, and shorten hospital stays after colorectal cancer surgery.
探讨畅通膏对结直肠癌术后胃肠功能的影响。
回顾性分析2021年6月至2023年6月在川北医学院附属医院接受结直肠癌手术的216例患者的临床资料。根据治疗方案将患者分为两组：对照组（n = 109），接受腹部多源治疗性照射；研究组（n = 107），在接受相同腹部照射治疗的基础上加用畅通膏。比较两组患者的血液流变学、胃肠激素、免疫功能、癌因性疲乏、生活质量、胃肠功能、住院时间及临床疗效。
治疗后，两组患者的血浆黏度、红细胞沉降率、高切和低切全血黏度、生长抑素（SS）、血管活性肠肽（VIP）及修订版派珀疲乏量表（PFS-R）评分均较治疗前显著降低，且研究组降低更明显。相反，治疗后胃动素（MTL）、免疫球蛋白G（IgG）、IgA、IgM水平及生活质量问卷（QLQ-C30）评分显著升高，且研究组升高更明显（P < 0.05）。此外，研究组胃肠功能恢复指标及住院时间均短于对照组（P < 0.05）。研究组的总临床有效率（94.39%）高于对照组（84.40%）（P < 0.05）。
畅通膏疗法可有效调节血液流变学，改善胃肠激素水平，促进胃肠及免疫功能恢复，减轻癌因性疲乏，提高生活质量，并缩短结直肠癌术后的住院时间。
