Fu Haixiang, Wang Wei, Chen Yuhe
Department of Orthopedics, Lu'an Hospital of PKU HealthCare Changzhi 046000, Shanxi, China.
Am J Transl Res. 2024 Nov 15;16(11):6457-6466. doi: 10.62347/XHHF1440. eCollection 2024.
To analyze the clinical effects of platelet-rich plasma (PRP) combined with arthroscopic microfracture (MF) in patients with knee cartilage injury.
Eighty cases of knee cartilage injury treated in Lu'an Hospital of PKU HealthCare during July 2019 and July 2021 were selected for this study. Patients were divided into a control group (CG, treated with MF alone, n=36) and an observation group (OG, treated with MG+PRP, n=44) based on their intervention regimen. Outcomes were compared between the two groups, including Hospital for Special Surgery (HSS) score, Tegner Activity Scale (TAS) score, Berg Balance Scale (BBS) score (joint balance function), Visual Analogue Scale (VAS) score, and Short-Form 36 Item Health Survey (SF-36) score, as well as levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and matrix metalloproteinase (MMP)-13. Furthermore, a binary logistic regression analysis was conducted to identify the factors influencing treatment efficacy in patients with knee cartilage injuries.
The overall response rate was significantly higher in the OG than in the CG. Factors such as sex, age, disease duration, lesion location, ICRS (International Cartilage Repair Society) grade, and treatment modality did not significantly affect treatment efficacy. The OG showed elevated HSS, TAS, and BBS scores after treatment, compared to baseline and the CG. Additionally, VAS scores and levels of TNF-α, IL-1β, and MMP-13 were notably lower compared with the baseline and the CG. In terms of life quality, patients in the OG scored markedly higher in dimensions of vitality, physiological function and social function, compared to both the pre-treatment values and CG.
PRP combined with MF outperformed MF alone in treating knee cartilage injury, which greatly improves patients' knee joint function and balance function, reduces pain, inhibits inflammation in the joint cavity, and enhances overall quality of life, with a favorable safety profile.
分析富血小板血浆（PRP）联合关节镜下微骨折术（MF）治疗膝关节软骨损伤患者的临床效果。
选取2019年7月至2021年7月在北大医疗六安医院接受治疗的80例膝关节软骨损伤患者进行本研究。根据干预方案将患者分为对照组（CG，单纯接受MF治疗，n = 36）和观察组（OG，接受MF + PRP治疗，n = 44）。比较两组的结果，包括特种外科医院（HSS）评分、 Tegner活动量表（TAS）评分、伯格平衡量表（BBS）评分（关节平衡功能）、视觉模拟量表（VAS）评分和简明健康状况调查（SF - 36）评分，以及肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1β和基质金属蛋白酶（MMP）-13的水平。此外，进行二元逻辑回归分析以确定影响膝关节软骨损伤患者治疗效果的因素。
观察组的总有效率显著高于对照组。性别、年龄、病程、病变部位、国际软骨修复协会（ICRS）分级和治疗方式等因素对治疗效果无显著影响。与基线和对照组相比，观察组治疗后HSS、TAS和BBS评分升高。此外，与基线和对照组相比，VAS评分以及TNF-α、IL-1β和MMP-13水平显著降低。在生活质量方面，与治疗前值和对照组相比，观察组患者在活力、生理功能和社会功能维度上的得分明显更高。
PRP联合MF治疗膝关节软骨损伤的效果优于单纯MF，能显著改善患者的膝关节功能和平衡功能，减轻疼痛，抑制关节腔内炎症，提高整体生活质量，且安全性良好。
