特应性皮炎与炎症性肠病风险之间的关联：纵向研究的荟萃分析
The Association Between Atopic Dermatitis and Inflammatory Bowel Disease Risk: A Meta-Analysis of Longitudinal Studies.
作者信息
Yu Pengfei, Lin Li, Xue Kaiyuan, Yang Jingwen, Wang Shanshan, An Yuepeng, Yang Suqing
机构信息
The First Clinical College of Heilongjiang University of Traditional Chinese Medicine Harbin People's Republic of China.
Department of Dermatology, The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine Harbin People's Republic of China.
出版信息
JGH Open. 2024 Dec 12;8(12):e70077. doi: 10.1002/jgh3.70077. eCollection 2024 Dec.
AIMS
This review aimed to investigate whether atopic dermatitis (AD) increases the risk of inflammatory bowel disease (IBD) by analyzing data from longitudinal studies.
METHODS
Cohort and case-control studies evaluating the association between AD and the risk of IBD, Crohn's disease (CD), or ulcerative colitis (UC) were included. Literature searches were conducted in PubMed, CENTRAL, Embase, Scopus, and Web of Science databases up to April 15, 2024.
RESULTS
A total of eight retrospective cohort studies comprising 61 190 816 participants were included. Meta-analysis revealed that AD significantly increased the risk of IBD (OR: 1.37, 95% CI: 1.31-1.43) without statistical heterogeneity. Further pooled analysis showed that AD was a significant risk factor for CD (OR: 1.51, 95% CI: 1.31-1.76) and UC (OR: 1.33, 95% CI: 1.13-1.56), with high inter-study heterogeneity ( = 83% and 89%, respectively). Sensitivity analyses confirmed the robustness of the results.
CONCLUSION
AD is associated with an increased risk of IBD, significantly elevating the risk of both CD and UC.
目的
本综述旨在通过分析纵向研究的数据，调查特应性皮炎（AD）是否会增加炎症性肠病（IBD）的风险。
方法
纳入评估AD与IBD、克罗恩病（CD）或溃疡性结肠炎（UC）风险之间关联的队列研究和病例对照研究。截至2024年4月15日，在PubMed、CENTRAL、Embase、Scopus和Web of Science数据库中进行了文献检索。
结果
共纳入八项回顾性队列研究，包括61190816名参与者。荟萃分析显示，AD显著增加了IBD的风险（比值比：1.37，95%置信区间：1.31 - 1.43），且无统计学异质性。进一步的汇总分析表明，AD是CD（比值比：1.51，95%置信区间：1.31 - 1.76）和UC（比值比：1.33，95%置信区间：1.13 - 1.56）的显著危险因素，研究间异质性较高（分别为83%和89%）。敏感性分析证实了结果的稳健性。
结论
AD与IBD风险增加相关，显著提高了CD和UC的风险。
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